Edward L. Amorosi, M.D.

Postchemotherapy histiocyte-rich pseudotumor involving the spleen
Chandra, Pranil; Wen, Yong Hannah; Tuli, Sandeep; Raphael, Bruce G; Amorosi, Edward L; Medeiros, L Jeffrey; Ibrahim, Sherif
2009 Sep;132(3):342-348, American journal of clinical pathology
We report 2 cases of splenic postchemotherapy histiocyte-rich pseudotumor. Each patient had a history of diffuse large B-cell lymphoma, treated with multiagent chemotherapy. Computed tomography scans performed on both patients showed splenic masses. A positron emission tomography scan performed on 1 patient showed increased metabolic activity. The preoperative diagnosis in both patients was recurrent lymphoma, prompting splenectomy. The splenectomy specimens showed multiple, tan-white, firm nodules, up to 3.5 cm in diameter, that were histologically composed of central necrotic B cells (CD20+/CD3-), consistent with necrotic lymphoma, surrounded by numerous lipid-laden (xanthomatous) histiocytes. Clinical staging studies at the time of splenectomy showed no other sites of disease. We conclude that these histologic and immunophenotypic findings represent chemotherapy-induced tumor necrosis with a florid histiocytic reaction mimicking residual viable lymphoma. Others have used descriptive terminology or the term xanthomatous pseudotumor for these lesions that have been only rarely reported in the spleen previously
— id: 114480, year: 2009, vol: 132, page: 342, stat: Journal Article,

EBV-associated diffuse large B-cell lymphoma in the immunocompetent: A clinicopathological study
Chandra, P; Goldenberg, A; Amorosi, E; Filiz, S
2006 SEP ;19(5):113-114, Modern pathology
— id: 69623, year: 2006, vol: 19, page: 113, stat: Journal Article,

FDG positron emission tomography of bone involvement in sarcoidosis
Aberg, Caroline; Ponzo, Fabio; Raphael, Bruce; Amorosi, Edward; Moran, Victor; Kramer, Elissa
2004 Apr;182(4):975-977, American journal of roentgenology
— id: 43828, year: 2004, vol: 182, page: 975, stat: Journal Article,

Transient atypical monocytosis mimic acute myelomonocytic leukemia in post-chemotherapy patients receiving G-CSF: report of two cases
Liu, C Z; Persad, R; Inghirami, G; Sen, F; Amorosi, E; Goldenberg, A; Ibrahim, S
2004 Oct;26(5):359-362, Clinical & laboratory haematology
Summary Granulocyte colony-stimulating factor (G-CSF) is now widely used in patients with malignant disorders receiving intensive chemotherapy to increase leukocyte count and to upregulate phagocyte function during neutropenia. Monocytosis associated with G-CSF has been reported in anecdotal literature. We report two cases of pseudoleukemia secondary to G-CSF administration. Both patients initially presented with myelodysplastic syndrome with chromosome 7 abnormalities that evolved into acute myeloid leukemia. Case one had deletion 7q while case two initially had monosomy 7 and subsequently developed a balanced translocation between the short (p) arm of chromosome 1 and long (q) arm of chromosome 15. Following the induction chemotherapy and G-CSF administration, both of these patients developed pseudoleukemia. Patient 1 had white blood cell (WBC) count of 26 x 10(9)/l with 72% monocytes, while patient two had WBC of 14.1 x 10(9)/l with 30% monocytes. In both patients the monocytosis resolved after the discontinuation of G-CSF therapy. In summary, patients treated with G-CSF should be followed closely. In those cases with pseudoleukemia discontinuation of the drug with no supplemental chemotherapy is probably enough to control the atypical monocytosis
— id: 45370, year: 2004, vol: 26, page: 359, stat: Journal Article,

High-grade T-cell lymphoma complicating B-cell chronic lymphocytic leukemia: an unusual manifestation of "Richter's syndrome"
Novogrudsky A; Amorosi EL; Gottesman SR
2001 Mar;66(3):203-206, American journal of hematology
Approximately 3% of patients with B-cell chronic lymphocytic leukemia (CLL) develop a high-grade large-cell lymphoma consistent with Richter's Syndrome. In most cases, these lymphomas are of B-cell origin and are believed to arise by clonal evolution from the CLL cells. We present a case of a patient with a 10-year history of B-CLL who developed an aggressive large-cell lymphoma, confirmed by immunophenotype to be of T-cell origin. We suggest that in patients with CLL, immunodysregulation can result in the proliferation of T cells, which may mutate and result in the development of a new malignant clone
— id: 26770, year: 2001, vol: 66, page: 203, stat: Journal Article,

MEIS1 and HOXA7 genes in human acute myeloid leukemia
Afonja O; Smith JE; Cheng DM; Goldenberg AS; Amorosi E; Shimamoto T; Nakamura S; Ohyashiki K; Ohyashiki J; Toyama K; Takeshita K
2000 Oct;24(10):849-855, Leukemia research
Co-activation of Meisl with Hoxa7 or Hoxa9 homeobox genes by retroviral gene insertion has recently been reported to be leukemogenic in murine myeloid leukemia. In this study we determined their expression in human leukemia. Most human myeloid leukemia cell lines co-expressed MEIS1 with HOXA7 and HOXA9. Among patients with acute leukemia, 50% of AML patients expressed MEIS1, while the majority of ALL patients were negative. A total of 89.5% of patients expressing MEIS1 co-expressed HOXA7. In unadjusted models, poorer response to chemotherapy was associated with expression of HOXA7 regardless of MEIS1 status and older patients were more likely to express either gene
— id: 17839, year: 2000, vol: 24, page: 849, stat: Journal Article,

Apoptotic index from fine needle aspiration cytology as a criterion to predict histologic grade of non-Hodgkin's lymphoma
Symmans WF; Cangiarella JF; Symmans PJ; Cohen JM; Yee HT; Bennett G; Amorosi EL; Waisman J
2000 Mar-Apr;44(2):194-204, Acta cytologica
OBJECTIVE: To investigate whether the assessment of apoptotic index (AI) from fine needle aspiration (FNA) smears of non-Hodgkin's lymphomas (NHL) is reliable and has potential utility as a criterion to predict histologic grade. STUDY DESIGN: AI was independently determined by four cytopathologists as a percentage from routine FNA smears in 96 NHLs and 15 lymphoid hyperplasias. Working formulation (WF) grades from corresponding surgical biopsies were modified to include mantle zone-derived NHLs as intermediate grade and to make diffuse large cell NHL a separate category called 'high' grade, whereas WF high grade NHLs were called 'very high' grade. Histologic grades were also derived from the Revised European American Lymphoma (REAL) classification. AI was compared with histologic grade using the unpaired, two-tailed Student t test. These data were used to determine potential thresholds for AI that separate lower from higher grade NHLs. RESULTS: Measurements of AI strongly correlated between cytopathologists (median r = .93). Low and intermediate grade NHLs had indistinguishable AIs, whereas higher grade NHLs had significantly higher AIs. Appropriate potential AI thresholds between low or intermediate grade and higher grade NHLs were in the range of 1.5-2.5% (modified WF) and 1-2% (REAL). CONCLUSION: There is excellent interobserver reliability in the measurement of AI from FNAs of NHLs. Higher AIs distinguish higher from lower grade NHLs. Diffuse large cell NHLs had AIs that were similar to WF high grade NHLs
— id: 11783, year: 2000, vol: 44, page: 194, stat: Journal Article,

Peripheral T cell lymphoma in a patient with common variable immunodeficiency disease: case report and literature review
Gottesman, S R; Haas, D; Ladanyi, M; Amorosi, E L
1999 Feb;32(5-6):589-595, Leukemia & lymphoma
This report documents the occurrence of a peripheral T cell lymphoma arising in the bone marrow and liver of a patient with common variable immunodeficiency disease. The T cell origin of this lymphoma was demonstrated by immunohistochemical phenotyping and gene rearrangement studies and was not associated with EBV infection of the lymphoma cells. The frequency and characteristics of lymphomas complicating CVID are reviewed
— id: 93600, year: 1999, vol: 32, page: 589, stat: Journal Article,

Multilineage involvement and erythropoietin-"independent" erythroid progenitor cells in a patient with systemic mastocytosis
Afonja O; Amorosi E; Ashman L; Takeshita K
1998 Oct;77(4):183-186, Annals of hematology
We report on a patient with systemic mastocytosis with an activating point mutation of the c-kit gene. This mutation was identical to the c-kit mutation recently described by other groups. Additionally, we found that in this patient the mutation was also present in myeloid and erythroid lineages, indicating a multilineage involvement and suggesting a clonal origin of the disease similar to that described in other myeloproliferative disorders. The erythroid involvement was further demonstrated by the presence of erythropoietin-'independent' erythroid progenitor cells
— id: 57015, year: 1998, vol: 77, page: 183, stat: Journal Article,

Feasibility of high dose busulfan and melphalan with autologous hematopoietic stem cell transplantation in multiple myeloma
Begum, U; Fitzgerald, D; Yong, LO; Grand, M; Thomas, U; Chen, Y; Patel, A; Goodman, D; Dillon, C; Amorosi, E; Cook, P
1997 NOV 15 ;90(10):4346-4346, Blood
— id: 53139, year: 1997, vol: 90, page: 4346, stat: Journal Article,

Large-cell variants of mantle cell lymphoma: cytologic characteristics and p53 anomalies may predict poor outcome
Zoldan MC; Inghirami G; Masuda Y; Vandekerckhove F; Raphael B; Amorosi E; Hymes K; Frizzera G
1996 May;93(2):475-486, British journal of haematology
Large-cell variants are uncommon in mantle cell lymphoma (MCL). Here we describe the pathologic and clinical findings in five patients with large-cell lymphoma related to MCL (L-MCL), and compare them to a group of classic small-cell MCL (s-MCL) cases. Histologically, the MC origin of the large cells was evinced by their association with a small mantle cell component in the same tissue, or their distribution in a classic mantle zone pattern, or their development in a patient with previous s-MCL. The large cells were either pleomorphic mantle cells (case 1) or transformed blast-like cells (case 2-5). The median nuclear diameter, median nuclear area and proliferation index of L-MCLs and s-MCLs, were statistically different. Immunophenotypic characterization of four specimens of L-MCL and 10 of s-MCLs with a large panel of antibodies showed the classic findings of MCL, i.e. the IgM+ D+/-, CD5+, CD10-, CD23- phenotype in all cases except two (one CD5- and one CD23+), and the association with a loose follicular dendritic cell network. Two of four L-MCLs and 5/10 s-MCLs demonstrated rearrangements of the bcl-1 gene by Southern blot or by polymerase chain reaction (PCR); 2/4 L-MCLs and 1/9 s-MCLs had p53 mutations on single-strand conformation polymorphism analysis; none of the 14 specimens showed rearrangement of bcl-2 by PCR or bcl-6 and c-myc by Southern blot. All patients with 'transformed' histology (versus 37% of all others) died of lymphoma; their survival (15-18 months; median 17) was much shorter than that of all the others (28-117+ months; median 43) (P=0.0035). All three patients with p53 anomalies, two of whom had tumours with transformed histology, died of their disease in a short time (15, 18 and 28 months). In contrast, the presence of bcl-1 rearrangements did not have prognostic implications. This study documents the existence of large-cell variants of MCL and the poor prognosis associated with the 'transformed' cytologic type and/or p53 abnormalities
— id: 56901, year: 1996, vol: 93, page: 475, stat: Journal Article,

Morphological, ultrastructural, and genetic characterization of an unusual T-cell lymphoma in a patient with sinus histiocytosis with massive lymphadenopathy
Koduru PR; Susin M; Kolitz JE; Soni M; Teichberg S; Siques MJ; Sun T; Amorosi E; Budman DR
1995 Mar;48(3):192-200, American journal of hematology
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare benign disease of unknown etiology. It is rarely associated with malignant lymphoma. This report documents the first case of a T-cell lymphoma, which developed in a patient with a 10-year history of SHML. The disease was complicated by hypereosinophilia and massive retroperitoneal lymphadenopathy. Histological examination of a cervical lymph node biopsy during the terminal phase identified a lymphoma composed of cells with morphological plasmacytoid features. Ultrastructurally, the tumor cells showed poorly developed cytoplasm, nuclei with peripheral chromatin clumping, and inconspicuous nucleoli. Cytogenetic studies showed two related clones. On immunohistochemical staining tumor cells were positive with monoclonal antibodies (mAb) CD3 and CD45RO. Southern blotting analysis identified clonal rearrangements in the T-cell receptor (TCR) alpha, beta and gamma genes. Thus, T-cell lineage of the tumor cells was established. In situ hybridization of interleukin-2 (IL-2) and interleukin-5 (IL-5) cDNA probes on tissue sections identified the synthesis of IL-5 by the eosinophils, suggesting an autocrine pathway of eosinophilopoiesis leading to hypereosinophilia in this patient
— id: 22096, year: 1995, vol: 48, page: 192, stat: Journal Article,

A paraneoplastic mixed bullous skin disease associated with anti-skin antibodies and a B-cell lymphoma
Bystryn JC; Hodak E; Gao SQ; Chuba JV; Amorosi EL
1993 Jul;129(7):870-875, Archives of dermatology
BACKGROUND--The full spectrum of bullous diseases associated with underlying cancers remains to be fully defined. OBSERVATION--We describe a patient with a mixed bullous disease exhibiting combined features of cicatricial pemphigoid and pemphigus and associated with a B-cell lymphoma producing an IgM paraprotein to intercellular antigens in human skin. The patient had the clinical features of cicatricial pemphigoid and the histologic and immunofluorescence abnormalities of both cicatricial pemphigoid and pemphigus. These included oral and cutaneous erosions; ocular scarring; subbasal and acantholytic intraepidermal bullae; and circulating and tissue-fixed basement membrane zone and intercellular antibodies. The antibodies were directed to a 140-kd antigen in dermal extracts of skin split with 1 mol/L of sodium chloride and to antigens with approximate molecular weights of 150, 180, 230, and 285 kd in the dermal extract. In contrast to paraneoplastic pemphigus, the intercellular antibodies did not react to mammalian bladder. The intercellular antibodies were of the IgM class and were associated with the paraprotein produced by the malignant B cells. CONCLUSIONS--We believe that this condition represents a novel bullous disease, which we refer to as paraneoplastic mixed bullous disease. This condition illustrates that distinct bullous diseases are associated with paraneoplastic syndromes and that at least one possible mechanism for such eruptions is the production of anti-skin antibodies by malignant B cells
— id: 13122, year: 1993, vol: 129, page: 870, stat: Journal Article,

Immunophenotypic evaluation of the bone marrow in non-Hodgkin's lymphoma
Fineberg S; Marsh E; Alfonso F; Espiritu E; Gottesman SR; Amorosi E; Feiner HD
1993 Jun;24(6):636-642, Human pathology
Immunophenotypic evaluations of the bone marrow (BM) are reported on 69 aspirates from 58 patients who had non-Hodgkin's lymphoma or chronic lymphocytic leukemia involving the BM. Using flow cytometry and immunofluorescence microscopy on density gradient isolated BM mononuclear cells, the neoplasm could be identified and characterized in 59 aspirates (86%) from 49 patients (84%). Using International Working Formulation guidelines the neoplasms were classified on the basis of prior or subsequent histopathology of lymph node, spleen, skin, or other soft tissue site, or by evaluation of peripheral blood in chronic lymphocytic leukemia. In nine cases the lymphoma could not be completely classified according to International Working Formulation guidelines because only BM was available for evaluation. The neoplasm in the BM was identified and characterized immunophenotypically in all 29 cases of chronic lymphocytic leukemia/well-differentiated lymphocytic lymphoma (WDLL) (100%), in 11 of 12 cases of low-grade lymphoma other than WDLL (92%), in 11 of 15 cases of intermediate-grade lymphoma (73%), and in two of four cases of high-grade lymphoma (50%). Six of the nine cases not classified by International Working Formulation guidelines could be characterized immunophenotypically. In 10 cases immunophenotypic studies revealed negative findings, although the concurrent core biopsy specimens were positive. In two cases immunophenotypic studies with positive findings accompanied a negative core biopsy specimen. A panel of immunohistochemical reagents reactive with fixative/paraffin-resistant antigens was used for a retrospective evaluation of the 69 core biopsy specimens. When compared with the immunophenotypic data obtained from the marrow aspirates these results proved to be only moderately reliable in B-lineage neoplasms and unreliable in T-cell neoplasms. Thus, immunophenotyping of aspirated marrow by flow cytometry was found to be the most reliable method for determining the antigenic profiles of BM-based lymphomas
— id: 13142, year: 1993, vol: 24, page: 636, stat: Journal Article,

IMMUNOPHENOTYPE (IP) EVALUATION OF THE BONE-MARROW (BM) IN NONHODGKINS LYMPHOMA (NHL)
FINEBERG, S; MARSH, E; GOTTESMAN, S; ALFONSO, F; ESPIRITU, E; AMOROSI, E; FEINER, H
1991 ;64(Suppl 1):A72-A72, Laboratory investigation
— id: 51737, year: 1991, vol: 64, page: A72, stat: Journal Article,

IMMUNOPHENOTYPIC ANALYSIS OF THE BONE-MARROW (BM) OF 36 PATIENTS WITH DYSPROTEINEMIA
Bannan, M; Finfer, M; Kallman, J; Amorosi, E; Rizk, C; Chuba, J; Feiner, H
1990 ;62(Suppl 1):A7-A7, Laboratory investigation
— id: 32015, year: 1990, vol: 62, page: A7, stat: Journal Article,

IgM monoclonal gammopathy/Waldenstrom's macroglobulinemia: a morphological and immunophenotypic study of the bone marrow
Feiner HD; Rizk CC; Finfer MD; Bannan M; Gottesman SR; Chuba JV; Amorosi E
1990 Jun;3(3):348-356, Modern pathology
The presence of a monoclonal paraprotein in the serum or urine raises the possibility of myeloma or lymphoma/leukemia. Yet, in a significant proportion of individuals with serum paraproteins, particularly those with low levels of paraprotein, clinical and routine bone marrow evaluation is not diagnostic of an underlying neoplasm. The purpose of this study was to define the pathologic basis for macroglobulinemia in patients whose routine bone marrow biopsies were not diagnostic of a lymphoplasmacytic neoplasm. We used immunofluorescence microscopy and flow cytometry of cell suspensions prepared from aspirated marrow, as well as immunohistochemistry of core biopsies, to perform immunopathologic evaluations of the bone marrow from 16 such patients. Seven individuals without a monoclonal serum paraprotein, who were similarly studied, served as controls. Our data indicate that 13 of the 16 patients with monoclonal serum IgM paraproteins whose routine bone marrow biopsies were normal or showed nondiagnostic changes morphologically had a dispersed monotypic B lineage population of concordant immunoglobulin heavy and light chain type in the bone marrow. The immunophenotype of these cells spanned the range from mature B cell to plasmacytoid B cell to plasma cell. In four of these 13 patients a diagnosis of lymphoplasmacytic lymphoma could be made on the basis of greater than or equal to 20% monoclonal B lineage cells among bone marrow mononuclear cells
— id: 45918, year: 1990, vol: 3, page: 348, stat: Journal Article,

Neutropenic typhlitis simulating carcinoma of the cecum
Musher DR; Amorosi EL; Gouge T; Megibow AJ; Press RA
1989 Sep-Oct;35(5):449-451, Gastrointestinal endoscopy
— id: 10496, year: 1989, vol: 35, page: 449, stat: Journal Article,

The association of progressive, atrophying, chronic, granulomatous dermohypodermitis with Hodgkin's disease
Benisovich V; Papadopoulos E; Amorosi EL; Zucker-Franklin D; Silber R
1988 Dec 1;62(11):2425-2429, Cancer
The case of a patient with an unusual skin disorder--progressive, atrophying, chronic, granulomatous dermohypodermitis (PACGD)--who developed Hodgkin's disease is reported. A review of the literature revealed only two other cases of PACGD, one of which affected a patient who also was found to have Hodgkin's disease. In an additional report, the diagnosis of Hodgkin's disease was made in a patient who may have had the same dermatologic disorder. The case is reported because the association of these two rare diseases is believed to be more than a chance event
— id: 10879, year: 1988, vol: 62, page: 2425, stat: Journal Article,

THE KARYOTYPE OF PHILADELPHIA CHROMOSOME-NEGATIVE, BCR REARRANGEMENT-POSITIVE CHRONIC MYELOID-LEUKEMIA
Weinstein, ME; Grossman, A; Perle, MA; Wilmot, PL; Verma, RS; Silver, RT; Arlin, Z; Allen, SL; Amorosi, E; Waintraub, SE; Shapiro, LR; Benn, PA
1988 Oct 15;35(2):223-229, Cancer genetics & cytogenetics
— id: 31573, year: 1988, vol: 35, page: 223, stat: Journal Article,

IMMUNOHISTOLOGICAL ANALYSIS OF ROSAI-DORFMAN HISTIOCYTOSIS - A DISEASE OF S-100+CD1-HISTIOCYTES
Bonetti, F; Chilosi, M; Menestrina, F; Scarpa, A; Pelicci, PG; Amorosi, E; Fioredonati, L; Knowles, DM
1987 Jun;411(2):129-135, Virchows archiv A. Pathological anatomy & histopathology
— id: 31324, year: 1987, vol: 411, page: 129, stat: Journal Article,

Simultaneous occurrence of mycosis fungoides and Hodgkin disease: clinical and histologic correlations in three cases with ultrastructural studies in two
Hawkins, K A; Schinella, R; Schwartz, M; Ramsey, D; Weintraub, A H; Silber, R; Amorosi, E L
1983 Jun;14(4):355-362, American journal of hematology
We present three patients who manifested both Hodgkin disease and mycosis fungoides. Ages ranged from 39 to 66 and two were male. Skin lesions were present from 3 to 40 years before the diagnosis of Hodgkin disease. In all cases, mycosis fungoides was confirmed histologically by skin biopsy; the clinical course of the mycosis fungoides was indolent in all cases. Hodgkin disease was confirmed histologically in three, and confirmed by electron microscopy in two. All three patients responded to appropriate treatment for Hodgkin disease and are alive and well at the present time
— id: 93601, year: 1983, vol: 14, page: 355, stat: Journal Article,

Autoimmune thrombocytopenic purpura in homosexual men
Morris L; Distenfeld A; Amorosi E; Karpatkin S
1982 Jun;96(6 Pt 1):714-717, Annals of internal medicine
Since November 1980 we have diagnosed 11 cases of severe autoimmune thrombocytopenic purpura in homosexual men; their mean platelet count (+/- SE) was 16 000 +/- 3000/mm3. All patients have been sexually active with multiple partners and exposed to numerous viruses and drugs. During this period, we also have diagnosed 20 cases of classic autoimmune thrombocytopenic purpura in heterosexual persons, with a normal women to men ratio of 3:1. Eight of nine homosexual patients had elevated platelet IgG compared with normal values in eight of 10 homosexual control subjects having normal hemograms (p less than 0.01). All responded moderately or completely to steroids. The three patients who had splenectomy had excellent responses. Four of five patients had a decreased helper/suppressor T cell ratio compared to healthy controls (p less than 0.001). Circulating immune complexes and total gamma globulin levels were elevated and lymphocytes relatively decreased in homosexual patients compared with homosexual controls (p less than 0.05). Thus, some sexually-active homosexual men seem to have an increased incidence of an immune regulation disorder directed against platelets
— id: 14941, year: 1982, vol: 96, page: 714, stat: Journal Article,

INCREASED APPARENT AUTOIMMUNE THROMBOCYTOPENIC PURPURA (ATP) IN HOMOSEXUAL MEN
Morris, L; Distenfeld, A; Amorosi, E; Karpatkin, S
1982 ;30(2):A324-A324, Clinical research
— id: 30557, year: 1982, vol: 30, page: A324, stat: Journal Article,

KAPOSIS SARCOMA AND THE HLA-DR5 ALLOANTIGEN - REPLY
Morris, L; Distenfeld, A; Amorosi, E; Karpatkin, S
1982 ;97(4):617-617, Annals of internal medicine
— id: 30520, year: 1982, vol: 97, page: 617, stat: Journal Article,

Evolution of Sezary syndrome in the course of hairy cell leukemia
Zucker-Franklin D; Amorosi EL; Ritz ND
1982 Jun;59(6):1181-1190, Blood
A patient with a history of 'leukemia' for 19 yr and documented hairy cell (HC) leukemia for 10 yr developed mycosis fungoides and the Sezary syndrome. The manifestations of both diseases were diagnostic on clinical and pathologic grounds. Ultrastructural, immunohistochemical, and surface marker techniques proved the HC to have phenotypic characteristics of the T-helper subset of lymphocytes to which the Sezary cells (SC) also belonged. Both types of cells contained tartrate-resistant acid phosphatase. HC did not infiltrate the skin. SC did not contain ribosome lamellar complexes. Because of otherwise overlapping morphology and the apparent replacement of HC by SC, it is likely that the Sezary cells constituted a genetic variant of the original neoplastic clone represented by the hairy cells. Since the biologic and therapeutic implications of such clonal evolution may be important, subtle phenotypic changes should be looked for repeatedly in patients with these diseases
— id: 61763, year: 1982, vol: 59, page: 1181, stat: Journal Article,

UNILATERAL LEG EDEMA - REPLY
HAWKINS, KA; AMOROSI, EL; SILBER, R
1981 ;246(15):1660-1660, JAMA
— id: 40190, year: 1981, vol: 246, page: 1660, stat: Journal Article,

CYCLIC ALTERATIONS IN LYMPHOCYTE FUNCTION DURING CYCLIC NEUTROPENIA
Borkowsky, W; Shenkman, L; Suleski, P; Rausen, A; Amorosi, E
1980 ;14(4):531-531, Pediatric research
— id: 28132, year: 1980, vol: 14, page: 531, stat: Journal Article,

Unilateral leg edema. A symptom of lymphoma
Hawkins KA; Amorosi EL; Silber R
1980 Dec 12;244(23):2640-2641, JAMA
— id: 65731, year: 1980, vol: 244, page: 2640, stat: Journal Article,

Procainamide-induced agranulocytosis and thrombocytopenia
Rothman, I K; Amorosi, E L
1979 Feb;139(2):246-247, Archives of internal medicine
Procainamide therapy has frequently been reported as a cause of agranulocytosis, but severe thrombocytopenia associated with the use of this drug has been noted only once. We report a case of simultaneously occurring agranulocytosis and profound thrombocytopenia in a patient receiving procainamide hydrochloride. Different mechanisms appeared to be responsible for the two cytopenias
— id: 93602, year: 1979, vol: 139, page: 246, stat: Journal Article,

Antiplatelet treatment of thrombotic thrombocytopenic purpura
Amorosi EL; Karpatkin S
1977 Jan;86(1):102-106, Annals of internal medicine
— id: 14979, year: 1977, vol: 86, page: 102, stat: Journal Article,

Platelet heterogeneity
Karpatkin S; Amorosi EL
1977 Apr;35(4):681-684, British journal of haematology
— id: 14976, year: 1977, vol: 35, page: 681, stat: Journal Article,

Acute manifestations of platelet dysfunction
Amorosi, E L
1973 Nov;57(6):1599-1608, Medical clinics of North America
— id: 93603, year: 1973, vol: 57, page: 1599, stat: Journal Article,

Streptococcal peritonitis in a patient with Hodgkin's disease and an intrauterine contraceptive device
Culliford AT; Harris MN; Porges RF; Berczeller PH; Amorosi EL; Grier WR
1973 Sep 15;117(2):288-290, American journal of obstetrics & gynecology
— id: 28953, year: 1973, vol: 117, page: 288, stat: Journal Article,

Circulating large platelets
Chatterji, A K; Lynch, E C; Garg, S K; Amorosi, E L; Karpatkin, S
1971 Jun 24;284(25):1440-1441, New England journal of medicine
— id: 15016, year: 1971, vol: 284, page: 1440, stat: Journal Article,

Use of the megathrombocyte as an index of megakaryocyte number
Garg, S K; Amorosi, E L; Karpatkin, S
1971 Jan 7;284(1):11-17, New England journal of medicine
— id: 15018, year: 1971, vol: 284, page: 11, stat: Journal Article,

Significance of splenomegaly in patients with hepatic cirrhosis and bleeding esophageal varices
Dumont, A E; Amorosi, E; Stahl, W M
1970 Apr;171(4):522-526, Annals of surgery
— id: 106807, year: 1970, vol: 171, page: 522, stat: Journal Article,

In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and GdMediterranean deficiency
Piomelli, S; Corash, L M; Davenport, D D; Miraglia, J; Amorosi, E L
1968 Apr;47(4):940-948, Journal of clinical investigation
A decreased level of glucose-6-phosphate dehydrogenase might result from decreased rate of synthesis, synthesis of an enzyme of lower catalytic efficiency, increased lability, or a combined mechanism. To test the hypothesis of increased lability, the rate of decline of the enzyme in vivo was measured in three groups of individuals, controls, Gd(-),A-males, and Gd(-), Mediterranean males, by the slope of decline of activity in fractions containing erythrocytes of progressively increasing mean age. These fractions were obtained by ultracentrifugation on a discontinuous density gradient of erythrocyte suspensions free of contaminating platelets and leukocytes.The rate of in vivo decline of pyruvate kinase (another age-dependent enzyme) was also measured and found very similar in the three groups.The in vivo decline of glucose-6-phosphate dehydrogenase was found to follow an exponential rate, with a half-life of 62 days for controls and 13 days for Gd(-),A- erythrocytes. The activity in normal reticulocytes was estimated at 9.7 U and in Gd(-),A- reticulocytes at 8.8 U. These estimates were confirmed by direct measurements in reticulocytes isolated from patients with extreme reticulocytosis.In Gd(-),Mediterranean erythrocytes activity could be demonstrated only in reticulocytes, which were estimated to average 1.4 U. The rate of decline is so extreme that no activity could be detected in mature erythrocytes.These data suggest that the glucose-6-phosphate dehydrogenase deficiency of both the Gd(A-) and the GdMediterranean variant results from different degrees of in vivo instability of the abnormal enzyme
— id: 93604, year: 1968, vol: 47, page: 940, stat: Journal Article,

[Progressive hypergammaglobulinemic hepatitis]
Miescher, P A; Braverman, A; Amorosi, E L
1966 Sep 2;91(35):1525-1532, Deutsche medizinische Wochenschrift
— id: 93605, year: 1966, vol: 91, page: 1525, stat: Journal Article,

Spur-shaped erythrocytes in Laennec's cirrhosis
Silber, R; Amorosi, E; Lhowe, J; Kayden, H J
1966 Sep 22;275(12):639-643, New England journal of medicine
— id: 101215, year: 1966, vol: 275, page: 639, stat: Journal Article,

HYPERSPLENISM
AMOROSI, E L
1965 Jul;39:249-285, Seminars in hematology
— id: 93606, year: 1965, vol: 39, page: 249, stat: Journal Article,