Mahgul M. Ali, M.D.

Analysis of Non-Modifiable Risk Factors for Intracranial Aneurysm Rupture in A Large, Retrospective Cohort
Amenta PS; Yadla S; Campbell PG; Maltenfort MG; Dey S; Ghosh S; Ali MS; Jallo JI; Tjoumakaris SI; Gonzalez LF; Dumont AS; Rosenwasser RH; Jabbour PM
2011 Sep 1;:?-?, Neurosurgery
BACKGROUND:: The risk factors predictive of intracranial aneurysm rupture remain incompletely defined. OBJECTIVE:: To examine the association between various non-modifiable risk factors and aneurysm rupture in a large cohort of patients evaluated at a single institution. METHODS:: A retrospective analysis of patients admitted to a cerebrovascular facility between January 2006 and 2010 with a primary diagnosis of cerebral aneurysm. Aneurysms were divided into two groups: unruptured or ruptured. The dome diameter, aspect ratio (AR), location, sidedness, neck morphology, and multiplicity were entered into a central database. A full model was constructed and systematic removal of the least significant variables was performed in a sequential fashion until only those variables reaching significance remained. RESULTS:: We identified 2347 patients harboring 5134 individual aneurysms, of which 34.90% were ruptured and 65.09% were unruptured. 25.89% of aneurysms with a dome diameter < 10 mm and 58.33% of aneurysms with a dome > 10mm were ruptured on admission (p<0.0001). 52.44% of aneurysms with an AR > 1.6 presented following a rupture (p<0.0001). The highest incidence of rupture (69.21%) was observed in aneurysms with an AR > 1.6, dome diameter < 10mm, and a deviated neck. Deviated neck-type aneurysms had a significantly greater incidence of rupture than classical neck-type aneurysms (p<0.0001). CONCLUSION:: An AR > 1.6, dome diameter > 10mm, a deviated neck, and right-sidedness are independently associated with aneurysm rupture
— id: 146980, year: 2011, vol: , page: ?, stat: Journal Article,

Computed tomography perfusion-based selection of patients for endovascular recanalization
Amenta, Peter S; Ali, Muhammad S; Dumont, Aaron S; Gonzalez, L Fernando; Tjoumakaris, Stavropoula I; Hasan, David; Rosenwasser, Robert H; Jabbour, Pascal
2011 Jun;30(6):E6-E6, Neurosurgical focus
Intravenous and intraarterial recombinant tissue plasminogen activator remains underutilized in the treatment of acute ischemic stroke, largely due to strict adherence to the concept of the therapeutic time window for administration. Recent efforts to expand the number of patients eligible for thrombolysis have been mirrored by an evolution in endovascular recanalization technology and techniques. As a result, there is a growing need to establish efficient and reliable means by which to select candidates for endovascular intervention beyond the traditional criteria of time from symptom onset. Perfusion imaging techniques, particularly CT perfusion used in combination with CT angiography, represent an increasingly recognized means by which to identify those patients who stand to benefit most from endovascular recanalization. Additionally, CT perfusion and CT angiography appear to provide sufficient data by which to exclude patients in whom there is little chance of neurological recovery or a substantial risk of postprocedure symptomatic intracranial hemorrhage. The authors review the current literature as it pertains to the limitations of time-based selection of patients for intervention, the increasing utilization of endovascular therapy, and the development of a CT perfusion-based selection of acute stroke patients for endovascular recanalization. Future endeavors must prospectively evaluate the utility and safety of CT perfusion-based selection of candidates for endovascular intervention
— id: 146974, year: 2011, vol: 30, page: E6, stat: Journal Article,

Cervical plexus block for carotid endarterectormy
Satyanarayana T; Ali M; Ramanathan S; Turndorf H; Chalon J
1981 ;55:A170-A170, Anesthesiology
— id: 47435, year: 1981, vol: 55, page: A170, stat: Journal Article,

Tracheobronchial cytologic changes and abnormal serum electrophoretic pattern during induced hypotension
O'Meara JB; Chalon J; Amirdivani M; Ali M; Day M; Turndorf H
1980 Apr;59(3):197-202, Anesthesia & analgesia
— id: 45834, year: 1980, vol: 59, page: 197, stat: Journal Article,

The humidification of anaesthetic gases: its importance and control
Chalon J; Ali M; Ramanathan S; Turndorf H
1979 Oct;26(5):361-366, Canadian Anesthetists' Society journal
— id: 45840, year: 1979, vol: 26, page: 361, stat: Journal Article,

Humidity and the anesthetized patient
Chalon J; Patel C; Ali M; Ramanathan S; Capan L; Tang CK; Turndorf H
1979 Mar;50(3):195-198, Anesthesiology
Damage to the ciliated cells of the tracheobronchial tree and incidence of postoperative pulmonary complications were measured by point-scoring systems in 202 patients who breathed dry and humidified anesthetic gases for 225 +/- 78 min. The incidence of postoperative pulmonary complications decreased as the humidity of administered anesthetic gases increased from 0 to 32.5 mg H2O/l. A similar relationship was found between the amount of inhaled moisture and the damage to the ciliated epithelium of the tracheobronchial tree. These results appear to indicate that a high inspired humidity is beneficial for operations on normothermic patients, and that cellular damage caused by dryness is a possible contributory factor in the production of the pulmonary atelectasis that follows stoppage of the mucociliary transport system in the immmediate postoperative period
— id: 23482, year: 1979, vol: 50, page: 195, stat: Journal Article,