Alan A Arslan

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Alan Arslan

Associate Professor, Department of Obstetrics and Gynecology;Associate Professor, Department of Environmental Medicine;Associate Professor, Department of Population Health
Obstetrics and Gynecology

Contact Info

Address
650 First Avenue
New York, NY 10016

212/263-1923
Alan.Arslan@nyumc.org

Education

— Dagestan Medical Academy, Russia, Medical Education

Research Summary

Dr. Arslan research interests focus on development of novel biomarkers for early detection of ovarian cancer, the second most common cancer of female reproductive tract and the leading cause of death from gynecologic neoplasms. Dr. Arslan has been awarded a New Investigator Award from the Department of Defense to study the role of soluble Fas, a marker of impaired apoptosis, as a potential biomarker of ovarian cancer.
Growing evidence suggests that inflammation may play an important role in development of cancer. Epidemiological evidence suggests that factors causing chronic inflammation of ovarian epithelium (asbestos/talc exposure, endometriosis and pelvic inflammatory disease) are also associated with an increased risk of ovarian cancer. Conversely, factors reducing local inflammation, such as tubal ligation and hysterectomy without oophorectomy, are associated with a reduced risk of ovarian cancer. These findings led to a hypothesis on a possible role of chronic inflammation in ovarian cancer. Dr. Arslan conducted a preliminary case-control study nested within the NYUWHS prospective cohort, which found that relative to no aspirin use, the odds ration for epithelial ovarian cancer among women who reported ever use of aspirin three or more times per week for a period of at least 6 months was 0.60 (95% confidence interval 0.26-1.38), after adjustment for age at menarche, parity, oral contraceptive use, and first-degree family history of breast cancer. The observed risk estimates are consistent with growing evidence suggesting that regular use of common anti-inflammatory drugs could be protective not only for colorectal cancer, as known previously, but also for ovarian cancer.
Dr. Arslan is a Principal Investigator of the currently ongoing NIH-funded research projects: R03 CA96428 "Biomarkers of Ovarian Cancer Risk"; R03 CA95923 "Pregnancy Hormonal Profiles as Biomarker of Breast Cancer Risk"; and R03 CA108394 "Serum Vitamin D, Genetic Polymorphisms & Ovarian Cancer".
Dr. Arslan is a co-investigator in the following active projects: "Estrogen Metabolites, Related Genes and Breast Cancer" (PI, Dr. R. Shore); "Pregnancy hormones and lifetime risk of breast cancer in mothers" (PI, Dr. P. Toniolo); "Reduction of Annexin-V in Antiphospholipid Pregnancy Loss" (PI, Dr. J. Rand).

Research Interests

Cancer Epidemiology; Biomarkers of Ovarian Cancer; Relationships between Reproductive Events and Cancer

Easy sonographic differential diagnosis between intrauterine pregnancy and cesarean section scar pregnancy in the early first trimester
Timor-Tritsch, Ilan E; Monteagudo, Ana; Cali, Giuseppe; Refaey, Hazem El; Agten, Andrea Kaelin; Arslan, Alan A. Easy sonographic differential diagnosis between intrauterine pregnancy and cesarean section scar pregnancy in the early first trimester. American journal of obstetrics & gynecology. 2016 Feb 17;:?-? (1965342)

Correction: Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk
Arem, Hannah; Yu, Kai; Xiong, Xiaoqin; Moy, Kristin; Freedman, Neal D; Mayne, Susan T; Albanes, Demetrius; Amundadottir, Laufey T; Arslan, Alan A; Austin, Melissa; Bamlet, William R; Beane-Freeman, Laura; Bracci, Paige; Canzian, Federico; Chanock, Stephen J; Cotterchio, Michelle; Duell, Eric J; Gallinger, Steve; Giles, Graham G; Goggins, Michael; Goodman, Phyllis J; Hartge, Patricia; Hassan, Manal; Helzlsouer, Kathy; Henderson, Brian; Holly, Elizabeth A; Hoover, Robert; Jacobs, Eric J; Kamineni, Aruna; Klein, Alison; Klein, Eric; Kolonel, Laurence N; Li, Donghui; Malats, Nuria; Mannisto, Satu; McCullough, Marjorie L; Olson, Sara H; Orlow, Irene; Peters, Ulrike; Petersen, Gloria M; Porta, Miquel; Severi, Gianluca; Shu, Xiao-Ou; Van Den Eeden, Stephen; Visvanathan, Kala; White, Emily; Yu, Herbert; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Tobias, Geoffrey S; Maeder, Dennis; Brotzman, Michelle; Risch, Harvey; Sampson, Joshua N; Stolzenberg-Solomon, Rachael Z. Correction: Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk. PLoS one. 2015 ;10(6):e0129983-e0129983 e0129983 (1615592)

Vitamin d metabolic pathway genes and pancreatic cancer risk
Arem, Hannah; Yu, Kai; Xiong, Xiaoqin; Moy, Kristin; Freedman, Neal D; Mayne, Susan T; Albanes, Demetrius; Arslan, Alan A; Austin, Melissa; Bamlet, William R; Beane-Freeman, Laura; Bracci, Paige; Canzian, Federico; Cotterchio, Michelle; Duell, Eric J; Gallinger, Steve; Giles, Graham G; Goggins, Michael; Goodman, Phyllis J; Hartge, Patricia; Hassan, Manal; Helzlsouer, Kathy; Henderson, Brian; Holly, Elizabeth A; Hoover, Robert; Jacobs, Eric J; Kamineni, Aruna; Klein, Alison; Klein, Eric; Kolonel, Laurence N; Li, Donghui; Malats, Nuria; Mannisto, Satu; McCullough, Marjorie L; Olson, Sara H; Orlow, Irene; Peters, Ulrike; Petersen, Gloria M; Porta, Miquel; Severi, Gianluca; Shu, Xiao-Ou; Visvanathan, Kala; White, Emily; Yu, Herbert; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Tobias, Geoffrey S; Maeder, Dennis; Brotzman, Michelle; Risch, Harvey; Sampson, Joshua N; Stolzenberg-Solomon, Rachael Z. Vitamin d metabolic pathway genes and pancreatic cancer risk. PLoS one. 2015 Mar 23;10(3):e0117574-e0117574 e0117574 (1513822)

The TERT gene harbors multiple variants associated with pancreatic cancer susceptibility
Campa, Daniele; Rizzato, Cosmeri; Stolzenberg-Solomon, Rachael; Pacetti, Paola; Vodicka, Pavel; Cleary, Sean P; Capurso, Gabriele; Bueno-de-Mesquita, H Bas; Werner, Jens; Gazouli, Maria; Butterbach, Katja; Ivanauskas, Audrius; Giese, Nathalia; Petersen, Gloria M; Fogar, Paola; Wang, Zhaoming; Bassi, Claudio; Ryska, Miroslav; Theodoropoulos, George E; Kooperberg, Charles; Li, Donghui; Greenhalf, William; Pasquali, Claudio; Hackert, Thilo; Fuchs, Charles S; Mohelnikova-Duchonova, Beatrice; Sperti, Cosimo; Funel, Niccola; Dieffenbach, Aida Karina; Wareham, Nicholas J; Buring, Julie; Holcatova, Ivana; Costello, Eithne; Zambon, Carlo-Federico; Kupcinskas, Juozas; Risch, Harvey A; Kraft, Peter; Bracci, Paige M; Pezzilli, Raffaele; Olson, Sara H; Sesso, Howard D; Hartge, Patricia; Strobel, Oliver; Malecka-Panas, Ewa; Visvanathan, Kala; Arslan, Alan A; Pedrazzoli, Sergio; Soucek, Pavel; Gioffreda, Domenica; Key, Timothy J; Talar-Wojnarowska, Renata; Scarpa, Aldo; Mambrini, Andrea; Jacobs, Eric J; Jamroziak, Krzysztof; Klein, Alison; Tavano, Francesca; Bambi, Franco; Landi, Stefano; Austin, Melissa A; Vodickova, Ludmila; Brenner, Hermann; Chanock, Stephen J; Delle Fave, Gianfranco; Piepoli, Ada; Cantore, Maurizio; Zheng, Wei; Wolpin, Brian M; Amundadottir, Laufey T; Canzian, Federico. The TERT gene harbors multiple variants associated with pancreatic cancer susceptibility. International journal of cancer. 2015 Jun 19;137(9):2175-2183 (1569122)

Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study
Clendenen, Tess V; Ge, Wenzhen; Koenig, Karen L; Axelsson, Tomas; Liu, Mengling; Afanasyeva, Yelena; Andersson, Anne; Arslan, Alan A; Chen, Yu; Hallmans, Goran; Lenner, Per; Kirchhoff, Tomas; Lundin, Eva; Shore, Roy E; Sund, Malin; Zeleniuch-Jacquotte, Anne. Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. PLoS one. 2015 Oct 21;10(10):e0140478-e0140478 e0140478 (1810082)