Alan A Arslan

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Alan Arslan

Associate Professor, Department of Obstetrics and Gynecology
Associate Professor, Department of Environmental Medicine
Associate Professor, Department of Population Health

Contact Info

650 First Avenue
New York, NY 10016



— Dagestan Medical Academy, Russia, Medical Education

Research Summary

Dr. Arslan research interests focus on development of novel biomarkers for early detection of ovarian cancer, the second most common cancer of female reproductive tract and the leading cause of death from gynecologic neoplasms. Dr. Arslan has been awarded a New Investigator Award from the Department of Defense to study the role of soluble Fas, a marker of impaired apoptosis, as a potential biomarker of ovarian cancer.
Growing evidence suggests that inflammation may play an important role in development of cancer. Epidemiological evidence suggests that factors causing chronic inflammation of ovarian epithelium (asbestos/talc exposure, endometriosis and pelvic inflammatory disease) are also associated with an increased risk of ovarian cancer. Conversely, factors reducing local inflammation, such as tubal ligation and hysterectomy without oophorectomy, are associated with a reduced risk of ovarian cancer. These findings led to a hypothesis on a possible role of chronic inflammation in ovarian cancer. Dr. Arslan conducted a preliminary case-control study nested within the NYUWHS prospective cohort, which found that relative to no aspirin use, the odds ration for epithelial ovarian cancer among women who reported ever use of aspirin three or more times per week for a period of at least 6 months was 0.60 (95% confidence interval 0.26-1.38), after adjustment for age at menarche, parity, oral contraceptive use, and first-degree family history of breast cancer. The observed risk estimates are consistent with growing evidence suggesting that regular use of common anti-inflammatory drugs could be protective not only for colorectal cancer, as known previously, but also for ovarian cancer.
Dr. Arslan is a Principal Investigator of the currently ongoing NIH-funded research projects: R03 CA96428 "Biomarkers of Ovarian Cancer Risk"; R03 CA95923 "Pregnancy Hormonal Profiles as Biomarker of Breast Cancer Risk"; and R03 CA108394 "Serum Vitamin D, Genetic Polymorphisms & Ovarian Cancer".
Dr. Arslan is a co-investigator in the following active projects: "Estrogen Metabolites, Related Genes and Breast Cancer" (PI, Dr. R. Shore); "Pregnancy hormones and lifetime risk of breast cancer in mothers" (PI, Dr. P. Toniolo); "Reduction of Annexin-V in Antiphospholipid Pregnancy Loss" (PI, Dr. J. Rand).

Research Keywords

cancer epidemiology, biomarkers of ovarian cancer, relationships between reproductive events and cancer

Placenta praevia and the risk of adverse outcomes during second trimester abortion: A retrospective cohort study
Perriera, Lisa K; Arslan, Alan A; Masch, Rachel. Placenta praevia and the risk of adverse outcomes during second trimester abortion: A retrospective cohort study. Australian & New Zealand journal of obstetrics & gynaecology. 2017 Feb;57(1):99-104 (2471192)

Serum biomarkers of polyomavirus infection and risk of lung cancer in never smokers
Malhotra, Jyoti; Waterboer, Tim; Pawlita, Michael; Michel, Angelika; Cai, Qiuyin; Zheng, Wei; Gao, Yu-Tang; Lan, Qing; Rothman, Nathaniel; Langseth, Hilde; Grimsrud, Tom K; Yuan, Jian-Min; Koh, Woon-Puay; Wang, Renwei; Arslan, Alan A; Zeleniuch-Jacquotte, Anne; Boffetta, Paolo. Serum biomarkers of polyomavirus infection and risk of lung cancer in never smokers. British journal of cancer. 2016 Oct 25;115(9):1131-1139 (2247082)

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21
Zhang, Mingfeng; Wang, Zhaoming; Obazee, Ofure; Jia, Jinping; Childs, Erica J; Hoskins, Jason; Figlioli, Gisella; Mocci, Evelina; Collins, Irene; Chung, Charles C; Hautman, Christopher; Arslan, Alan A; Beane-Freeman, Laura; Bracci, Paige M; Buring, Julie; Duell, Eric J; Gallinger, Steven; Giles, Graham G; Goodman, Gary E; Goodman, Phyllis J; Kamineni, Aruna; Kolonel, Laurence N; Kulke, Matthew H; Malats, Nuria; Olson, Sara H; Sesso, Howard D; Visvanathan, Kala; White, Emily; Zheng, Wei; Abnet, Christian C; Albanes, Demetrius; Andreotti, Gabriella; Brais, Lauren; Bueno-de-Mesquita, H Bas; Basso, Daniela; Berndt, Sonja I; Boutron-Ruault, Marie-Christine; Bijlsma, Maarten F; Brenner, Hermann; Burdette, Laurie; Campa, Daniele; Caporaso, Neil E; Capurso, Gabriele; Cavestro, Giulia Martina; Cotterchio, Michelle; Costello, Eithne; Elena, Joanne; Boggi, Ugo; Gaziano, J Michael; Gazouli, Maria; Giovannucci, Edward L; Goggins, Michael; Gross, Myron; Haiman, Christopher A; Hassan, Manal; Helzlsouer, Kathy J; Hu, Nan; Hunter, David J; Iskierka-Jazdzewska, Elzbieta; Jenab, Mazda; Kaaks, Rudolf; Key, Timothy J; Khaw, Kay-Tee; Klein, Eric A; Kogevinas, Manolis; Krogh, Vittorio; Kupcinskas, Juozas; Kurtz, Robert C; Landi, Maria T; Landi, Stefano; Le Marchand, Loic; Mambrini, Andrea; Mannisto, Satu; Milne, Roger L; Neale, Rachel E; Oberg, Ann L; Panico, Salvatore; Patel, Alpa V; Peeters, Petra H M; Peters, Ulrike; Pezzilli, Raffaele; Porta, Miquel; Purdue, Mark; Quiros, J Ramon; Riboli, Elio; Rothman, Nathaniel; Scarpa, Aldo; Scelo, Ghislaine; Shu, Xiao-Ou; Silverman, Debra T; Soucek, Pavel; Strobel, Oliver; Sund, Malin; Malecka-Panas, Ewa; Taylor, Philip R; Tavano, Francesca; Travis, Ruth C; Thornquist, Mark; Tjonneland, Anne; Tobias, Geoffrey S; Trichopoulos, Dimitrios; Vashist, Yogesh; Vodicka, Pavel; Wactawski-Wende, Jean; Wentzensen, Nicolas; Yu, Herbert; Yu, Kai; Zeleniuch-Jacquotte, Anne; Kooperberg, Charles; Risch, Harvey A; Jacobs, Eric J; Li, Donghui; Fuchs, Charles; Hoover, Robert; Hartge, Patricia; Chanock, Stephen J; Petersen, Gloria M; Stolzenberg-Solomon, Rachael S; Wolpin, Brian M; Kraft, Peter; Klein, Alison P; Canzian, Federico; Amundadottir, Laufey T. Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21. Oncotarget. 2016 Oct 11;7(41):66328-66343 (2232522)

Expression of Ezrin and Estrogen Receptors During Cervical Carcinogenesis
Fadiel, Ahmed; Choi, Seung Do; Park, Bora; Kim, Tae-Hee; Buldo-Licciardi, Julia; Ahmadi, Mitra; Arslan, Alan; Mittal, Khushbakhat; Naftolin, Frederick. Expression of Ezrin and Estrogen Receptors During Cervical Carcinogenesis. Reproductive sciences (Thousand Oaks, Calif.). 2016 Sep 29;:?-? (2262782)

Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium
Wentzensen, Nicolas; Poole, Elizabeth M; Trabert, Britton; White, Emily; Arslan, Alan A; Patel, Alpa V; Setiawan, V Wendy; Visvanathan, Kala; Weiderpass, Elisabete; Adami, Hans-Olov; Black, Amanda; Bernstein, Leslie; Brinton, Louise A; Buring, Julie; Butler, Lesley M; Chamosa, Saioa; Clendenen, Tess V; Dossus, Laure; Fortner, Renee; Gapstur, Susan M; Gaudet, Mia M; Gram, Inger T; Hartge, Patricia; Hoffman-Bolton, Judith; Idahl, Annika; Jones, Michael; Kaaks, Rudolf; Kirsh, Victoria; Koh, Woon-Puay; Lacey, James V Jr; Lee, I-Min; Lundin, Eva; Merritt, Melissa A; Onland-Moret, N Charlotte; Peters, Ulrike; Poynter, Jenny N; Rinaldi, Sabina; Robien, Kim; Rohan, Thomas; Sandler, Dale P; Schairer, Catherine; Schouten, Leo J; Sjoholm, Louise K; Sieri, Sabina; Swerdlow, Anthony; Tjonneland, Anna; Travis, Ruth; Trichopoulou, Antonia; van den Brandt, Piet A; Wilkens, Lynne; Wolk, Alicja; Yang, Hannah P; Zeleniuch-Jacquotte, Anne; Tworoger, Shelley S. Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium. Journal of clinical oncology. 2016 Aug 20;34(24):2888-2898 (2159102)