Iannis Aifantis

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Iannis Aifantis

Professor, Department of Pathology
Chair of the Department of Pathology

Contact Info

Address
522 First Avenue
New York, NY 10016

212/263-9898

Research Summary

Our laboratory studies the molecular mechanisms controlling hematopoietic stem cell (HSC) self-renewal, differentiation and transformation. More specifically we focus on the regulation of HSC cell cycle entry and on the effects of Notch signaling in stem cell differentiation. Finally, we study the role of the Notch pathway as an oncogenic trigger in acute lymphoblastic leukemia. Our goal is to design novel therapies that will target and suppress Notch transforming activity in vivo.

Research Keywords

cancer, developmental genetics, genome integrity, genomics, immunology, stem cell biology

HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking
Lazaris, Charalampos; Kelly, Stephen; Ntziachristos, Panagiotis; Aifantis, Iannis; Tsirigos, Aristotelis. HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. BMC genomics. 2017 Jan 05;18(1):22-22 (2386412)

Beating the Clock in T-Cell Acute Lymphoblastic Leukemia
Carroll, William L; Aifantis, Iannis; Raetz, Elizabeth A. Beating the Clock in T-Cell Acute Lymphoblastic Leukemia. Clinical cancer research. 2016 Dec 22;:?-? (2374552)

Alternative roles for oxidized mCs and TETs
Cimmino, Luisa; Aifantis, Iannis. Alternative roles for oxidized mCs and TETs. Current opinion in genetics & development. 2016 Dec 07;42:1-7 (2363242)

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis
Aranda-Orgilles, Beatriz; Saldana-Meyer, Ricardo; Wang, Eric; Trompouki, Eirini; Fassl, Anne; Lau, Stephanie; Mullenders, Jasper; Rocha, Pedro P; Raviram, Ramya; Guillamot, Maria; Sanchez-Diaz, Maria; Wang, Kun; Kayembe, Clarisse; Zhang, Nan; Amoasii, Leonela; Choudhuri, Avik; Skok, Jane A; Schober, Markus; Reinberg, Danny; Sicinski, Piotr; Schrewe, Heinrich; Tsirigos, Aristotelis; Zon, Leonard I; Aifantis, Iannis. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell stem cell. 2016 Dec 01;19(6):784-799 (2232392)

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia
Zhang, Jinghui; McCastlain, Kelly; Yoshihara, Hiroki; Xu, Beisi; Chang, Yunchao; Churchman, Michelle L; Wu, Gang; Li, Yongjin; Wei, Lei; Iacobucci, Ilaria; Liu, Yu; Qu, Chunxu; Wen, Ji; Edmonson, Michael; Payne-Turner, Debbie; Kaufmann, Kerstin B; Takayanagi, Shin-Ichiro; Wienholds, Erno; Waanders, Esme; Ntziachristos, Panagiotis; Bakogianni, Sofia; Wang, Jingjing; Aifantis, Iannis; Roberts, Kathryn G; Ma, Jing; Song, Guangchun; Easton, John; Mulder, Heather L; Chen, Xiang; Newman, Scott; Ma, Xiaotu; Rusch, Michael; Gupta, Pankaj; Boggs, Kristy; Vadodaria, Bhavin; Dalton, James; Liu, Yanling; Valentine, Marcus L; Ding, Li; Lu, Charles; Fulton, Robert S; Fulton, Lucinda; Tabib, Yashodhan; Ochoa, Kerri; Devidas, Meenakshi; Pei, Deqing; Cheng, Cheng; Yang, Jun; Evans, William E; Relling, Mary V; Pui, Ching-Hon; Jeha, Sima; Harvey, Richard C; Chen, I-Ming L; Willman, Cheryl L; Marcucci, Guido; Bloomfield, Clara D; Kohlschmidt, Jessica; Mrozek, Krzysztof; Paietta, Elisabeth; Tallman, Martin S; Stock, Wendy; Foster, Matthew C; Racevskis, Janis; Rowe, Jacob M; Luger, Selina; Kornblau, Steven M; Shurtleff, Sheila A; Raimondi, Susana C; Mardis, Elaine R; Wilson, Richard K; Dick, John E; Hunger, Stephen P; Loh, Mignon L; Downing, James R; Mullighan, Charles G. Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. Nature genetics. 2016 Dec;48(12):1481-1489 (2288612)