Iannis Aifantis

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Iannis Aifantis

Professor, Department of Pathology
Chair of the Department of Pathology

Contact Info

Address
522 First Avenue
New York, NY 10016

212-263-9898
Ioannis.Aifantis@nyumc.org

Research Summary

My laboratory focuses on molecular mechanisms of differentiation and transformation of hematopoietic stem cells and progenitors. More specifically, we focus on mechanisms of both lymphoid (T-ALL) and myeloid (AML, CML, CMML) leukemia initiation and progression. Our work has identified and studied a number of novel oncogenes (including NOTCH1), tumor suppressors (including FBXW7, TET2, CYLD, EZH2, UTX, cohesins) and downstream oncogenic signaling pathways. We have used these pathways to design molecularly targeted therapeutic protocols that inhibit the induction or affect the maintenance of the disease. Moreover, the laboratory is studying mechanisms of hematopoietic stem cell differentiation and self-renewal using both genomic and genetic approaches. Current areas of focus for our lab include the impact of DNA methylation in stem cell transformation, the mapping of long non-coding RNAs in a number of human tumors, the understanding of the impact of the 3D chromosomal architecture in cancer, the role of stress responses in human malignancy and the in vivo mapping of the tumor microenvironment for acute leukemia. Finally, we have recently expanded our scope and focused on the regulation of tumor progression and metastasis in selected solid tumors with an emphasis once again on cancer-initiation mechanisms that include protein stability, epigenetics and tumor microenvironment.

Research Keywords

cancer, immunology, stem cell biology, epigenetic regulation, leukemia, tumor microenvironment

Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex
Strikoudis, Alexandros; Lazaris, Charalampos; Ntziachristos, Panagiotis; Tsirigos, Aristotelis; Aifantis, Iannis. Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex. Cell cycle. 2017 Mar 8;:0-0 (2477122)

BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Valls, Ester; Lobry, Camille; Geng, Huimin; Wang, Ling; Cardenas, Mariano; Rivas, Martin; Cerchietti, Leandro; Oh, Philmo; Yang, Shao Ning; Oswald, Erin; Graham, Camille W; Jiang, Yanwen; Hatzi, Katerina; Agirre, Xabier; Perkey, Eric; Li, Zhuoning; Tam, Wayne; Bhatt, Kamala; Leonard, John P; Zweidler-McKay, Patrick A; Maillard, Ivan; Elemento, Olivier; Ci, Weimin; Aifantis, Iannis; Melnick, Ari. BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells. Cancer discovery. 2017 Feb 23;:?-? (2460312)

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome
Witkowski, Matthew T; Hu, Yifang; Roberts, Kathryn G; Boer, Judith M; McKenzie, Mark D; Liu, Grace J; Le Grice, Oliver D; Tremblay, Cedric S; Ghisi, Margherita; Willson, Tracy A; Horstmann, Martin A; Aifantis, Iannis; Cimmino, Luisa; Frietze, Seth; den Boer, Monique L; Mullighan, Charles G; Smyth, Gordon K; Dickins, Ross A. Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome. Journal of experimental medicine. 2017 Feb 11;214(3):773-791 (2449012)

HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking
Lazaris, Charalampos; Kelly, Stephen; Ntziachristos, Panagiotis; Aifantis, Iannis; Tsirigos, Aristotelis. HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. BMC genomics. 2017 Jan 05;18(1):22-22 (2386412)

Beating the Clock in T-Cell Acute Lymphoblastic Leukemia
Carroll, William L; Aifantis, Iannis; Raetz, Elizabeth A. Beating the Clock in T-Cell Acute Lymphoblastic Leukemia. Clinical cancer research. 2016 Dec 22;23(4):873-875 (2374552)