Ioannis Aifantis

Biosketch / Results /

Ioannis Aifantis

Hermann M. Biggs Professor of Pathology, Department of Pathology
Chair of the Department of Pathology

Contact Info

212/263-9898
Ioannis.Aifantis@nyumc.org

Research Interests

Our laboratory studies the molecular mechanisms controlling hematopoietic stem cell (HSC) self-renewal, differentiation and transformation. More specifically we focus on the regulation of HSC cell cycle entry and on the effects of Notch signaling in stem cell differentiation. Finally, we study the role of the Notch pathway as an oncogenic trigger in acute lymphoblastic leukemia. Our goal is to design novel therapies that will target and suppress Notch transforming activity in vivo.

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis
Aranda-Orgilles, Beatriz; Saldana-Meyer, Ricardo; Wang, Eric; Trompouki, Eirini; Fassl, Anne; Lau, Stephanie; Mullenders, Jasper; Rocha, Pedro P; Raviram, Ramya; Guillamot, Maria; Sanchez-Diaz, Maria; Wang, Kun; Kayembe, Clarisse; Zhang, Nan; Amoasii, Leonela; Choudhuri, Avik; Skok, Jane A; Schober, Markus; Reinberg, Danny; Sicinski, Piotr; Schrewe, Heinrich; Tsirigos, Aristotelis; Zon, Leonard I; Aifantis, Iannis. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell stem cell. 2016 Aug 24;:?-? (2232392)

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
Bonilla, Ximena; Parmentier, Laurent; King, Bryan; Bezrukov, Fedor; Kaya, Gurkan; Zoete, Vincent; Seplyarskiy, Vladimir B; Sharpe, Hayley J; McKee, Thomas; Letourneau, Audrey; Ribaux, Pascale G; Popadin, Konstantin; Basset-Seguin, Nicole; Chaabene, Rouaa Ben; Santoni, Federico A; Andrianova, Maria A; Guipponi, Michel; Garieri, Marco; Verdan, Carole; Grosdemange, Kerstin; Sumara, Olga; Eilers, Martin; Aifantis, Iannis; Michielin, Olivier; de Sauvage, Frederic J; Antonarakis, Stylianos E; Nikolaev, Sergey I. Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma. Nature genetics. 2016 Mar 7;48(4):398-406 (2024202)

The Impact of DNA Methylation in Hematopoietic Malignancies
Guillamot, Maria; Cimmino, Luisa; Aifantis, Iannis. The Impact of DNA Methylation in Hematopoietic Malignancies. Trends in cancer. 2016 Feb 1;2(2):70-83 (2059042)

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2
Inoue, Satoshi; Li, Wanda Y; Tseng, Alan; Beerman, Isabel; Elia, Andrew J; Bendall, Sean C; Lemonnier, Francois; Kron, Ken J; Cescon, David W; Hao, Zhenyue; Lind, Evan F; Takayama, Naoya; Planello, Aline C; Shen, Shu Yi; Shih, Alan H; Larsen, Dana M; Li, Qinxi; Snow, Bryan E; Wakeham, Andrew; Haight, Jillian; Gorrini, Chiara; Bassi, Christian; Thu, Kelsie L; Murakami, Kiichi; Elford, Alisha R; Ueda, Takeshi; Straley, Kimberly; Yen, Katharine E; Melino, Gerry; Cimmino, Luisa; Aifantis, Iannis; Levine, Ross L; De Carvalho, Daniel D; Lupien, Mathieu; Rossi, Derrick J; Nolan, Garry P; Cairns, Rob A; Mak, Tak W. Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. Cancer cell. 2016 Jul 14;30(2):337-348 (2185262)

Emerging concepts of epigenetic dysregulation in hematological malignancies
Ntziachristos, Panagiotis; Abdel-Wahab, Omar; Aifantis, Iannis. Emerging concepts of epigenetic dysregulation in hematological malignancies. Nature immunology. 2016 Aug 1;17(9):1016-1024 (2199412)