Ioannis Aifantis

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Ioannis Aifantis

Hermann M. Biggs Professor of Pathology, Department of Pathology
Chair of the Department of Pathology

Contact Info

212/263-9898
Ioannis.Aifantis@nyumc.org

Research Interests

Our laboratory studies the molecular mechanisms controlling hematopoietic stem cell (HSC) self-renewal, differentiation and transformation. More specifically we focus on the regulation of HSC cell cycle entry and on the effects of Notch signaling in stem cell differentiation. Finally, we study the role of the Notch pathway as an oncogenic trigger in acute lymphoblastic leukemia. Our goal is to design novel therapies that will target and suppress Notch transforming activity in vivo.

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
Bonilla, Ximena; Parmentier, Laurent; King, Bryan; Bezrukov, Fedor; Kaya, Gurkan; Zoete, Vincent; Seplyarskiy, Vladimir B; Sharpe, Hayley J; McKee, Thomas; Letourneau, Audrey; Ribaux, Pascale G; Popadin, Konstantin; Basset-Seguin, Nicole; Chaabene, Rouaa Ben; Santoni, Federico A; Andrianova, Maria A; Guipponi, Michel; Garieri, Marco; Verdan, Carole; Grosdemange, Kerstin; Sumara, Olga; Eilers, Martin; Aifantis, Iannis; Michielin, Olivier; de Sauvage, Frederic J; Antonarakis, Stylianos E; Nikolaev, Sergey I. Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma. Nature genetics. 2016 Mar 7;48(4):398-406 (2024202)

The Impact of DNA Methylation in Hematopoietic Malignancies
Guillamot, Maria; Cimmino, Luisa; Aifantis, Iannis. The Impact of DNA Methylation in Hematopoietic Malignancies. Trends in cancer. 2016 Feb 1;2(2):70-83 (2059042)

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2
Inoue, Satoshi; Li, Wanda Y; Tseng, Alan; Beerman, Isabel; Elia, Andrew J; Bendall, Sean C; Lemonnier, Francois; Kron, Ken J; Cescon, David W; Hao, Zhenyue; Lind, Evan F; Takayama, Naoya; Planello, Aline C; Shen, Shu Yi; Shih, Alan H; Larsen, Dana M; Li, Qinxi; Snow, Bryan E; Wakeham, Andrew; Haight, Jillian; Gorrini, Chiara; Bassi, Christian; Thu, Kelsie L; Murakami, Kiichi; Elford, Alisha R; Ueda, Takeshi; Straley, Kimberly; Yen, Katharine E; Melino, Gerry; Cimmino, Luisa; Aifantis, Iannis; Levine, Ross L; De Carvalho, Daniel D; Lupien, Mathieu; Rossi, Derrick J; Nolan, Garry P; Cairns, Rob A; Mak, Tak W. Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. Cancer cell. 2016 Jul 9;:?-? (2185262)

Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation
Proudhon, Charlotte; Snetkova, Valentina; Raviram, Ramya; Lobry, Camille; Badri, Sana; Jiang, Tingting; Hao, Bingtao; Trimarchi, Thomas; Kluger, Yuval; Aifantis, Iannis; Bonneau, Richard; Skok, Jane A. Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation. Cell reports. 2016 May 26;15(10):2159-2169 (2125032)

MODELING THE FUNCTION OF THE COHESIN COMPLEX IN HEMATOPOIETIC STEM CELL DIFFERENTIATION AND TRANSFORMATION
Aifantis, Iannis. MODELING THE FUNCTION OF THE COHESIN COMPLEX IN HEMATOPOIETIC STEM CELL DIFFERENTIATION AND TRANSFORMATION [Meeting Abstract]. Experimental hematology. 2015 SEP;43(9):S30-S30 (1795102)