Ioannis Aifantis

Biosketch / Results /

Ioannis Aifantis, Ph.D.

Professor; Chair of the Department of Pathology
Department of Pathology (Pathology)

« Back to Results

Education

1994-1996 — Masters in Science, "Molecular Biology and Genetics", University of Crete, Greece, Graduate Education
1996-1999 — Ph.D., "Immunology", University of Paris V, France, Graduate Education
1999-2003 — Harvard Medical School (Dana Farber Cancer Institute), USA, PostDoctoral Training

« Back to Results

All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes
Di Micco, Raffaella; Fontanals-Cirera, Barbara; Low, Vivien; Ntziachristos, Panagiotis; Yuen, Stephanie K; Lovell, Claudia D; Dolgalev, Igor; Yonekubo, Yoshiya; Zhang, Guangtao; Rusinova, Elena; Gerona-Navarro, Guillermo; Canamero, Marta; Ohlmeyer, Michael; Aifantis, Iannis; Zhou, Ming-Ming; Tsirigos, Aristotelis; Hernando, Eva
2014 Sep;:e1-e63, Cell reports
— id: 1259942, year: 2014, vol: , page: e1, stat: Journal Article,

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation
Gough, Daniel J; Marie, Isabelle J; Lobry, Camille; Aifantis, Iannis; Levy, David E
2014 Oct;124(14):2252-2261, Blood
— id: 1298802, year: 2014, vol: 124, page: 2252, stat: Journal Article,

Notch signaling: switching an oncogene to a tumor suppressor
Lobry, Camille; Oh, Philmo; Mansour, Marc R; Look, A Thomas; Aifantis, Iannis
2014 Apr;123(16):2451-2459, Blood
— id: 917732, year: 2014, vol: 123, page: 2451, stat: Journal Article,

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling
Ntziachristos, Panagiotis; Lim, Jing Shan; Sage, Julien; Aifantis, Iannis
2014 Mar;25(3):318-334, Cancer cell
— id: 868002, year: 2014, vol: 25, page: 318, stat: Journal Article,

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
Ntziachristos, Panagiotis; Tsirigos, Aristotelis; Welstead, G Grant; Trimarchi, Thomas; Bakogianni, Sofia; Xu, Luyao; Loizou, Evangelia; Holmfeldt, Linda; Strikoudis, Alexandros; King, Bryan; Mullanders, Jasper; Becksfort, Jared; Nedjic, Jelena; Paietta, Elisabeth; Tallman, Martin S; Rowe, Jacob M; Tonon, Giovanni; Satoh, Takashi; Kruidenier, Laurens; Prinjha, Rab; Akira, Shizuo; Van Vlierberghe, Pieter; Ferrando, Adolfo A; Jaenisch, Rudolf; Mullighan, Charles G; Aifantis, Iannis
2014 Aug;:1243-1244, Nature
— id: 1142252, year: 2014, vol: , page: 1243, stat: Journal Article,

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast
Rustighi, Alessandra; Zannini, Alessandro; Tiberi, Luca; Sommaggio, Roberta; Piazza, Silvano; Sorrentino, Giovanni; Nuzzo, Simona; Tuscano, Antonella; Eterno, Vincenzo; Benvenuti, Federica; Santarpia, Libero; Aifantis, Iannis; Rosato, Antonio; Bicciato, Silvio; Zambelli, Alberto; Del Sal, Giannino
2014 Jan;6(1):99-119, EMBO molecular medicine
— id: 781732, year: 2014, vol: 6, page: 99, stat: Journal Article,

Regulation of stem cell function by protein ubiquitylation
Strikoudis, Alexandros; Guillamot, Maria; Aifantis, Iannis
2014 Apr;15(4):365-382, EMBO reports
— id: 867132, year: 2014, vol: 15, page: 365, stat: Journal Article,

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia
Trimarchi, Thomas; Bilal, Erhan; Ntziachristos, Panagiotis; Fabbri, Giulia; Dalla-Favera, Riccardo; Tsirigos, Aristotelis; Aifantis, Iannis
2014 Jul;158(3):593-606, Cell
— id: 1090482, year: 2014, vol: 158, page: 593, stat: Journal Article,

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Abdel-Wahab, Omar; Gao, Jie; Adli, Mazhar; Dey, Anwesha; Trimarchi, Thomas; Chung, Young Rock; Kuscu, Cem; Hricik, Todd; Ndiaye-Lobry, Delphine; Lafave, Lindsay M; Koche, Richard; Shih, Alan H; Guryanova, Olga A; Kim, Eunhee; Li, Sheng; Pandey, Suveg; Shin, Joseph Y; Telis, Leon; Liu, Jinfeng; Bhatt, Parva K; Monette, Sebastien; Zhao, Xinyang; Mason, Christopher E; Park, Christopher Y; Bernstein, Bradley E; Aifantis, Iannis; Levine, Ross L
2013 Nov;210(12):2641-2659, Journal of experimental medicine
— id: 687442, year: 2013, vol: 210, page: 2641, stat: Journal Article,

Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers
Chaumeil, Julie; Micsinai, Mariann; Ntziachristos, Panagiotis; Deriano, Ludovic; Wang, Joy M-H; Ji, Yanhong; Nora, Elphege P; Rodesch, Matthew J; Jeddeloh, Jeffrey A; Aifantis, Iannis; Kluger, Yuval; Schatz, David G; Skok, Jane A
2013 Feb;3(2):359-370, Cell reports
— id: 242262, year: 2013, vol: 3, page: 359, stat: Journal Article,

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage
Chaumeil, Julie; Micsinai, Mariann; Ntziachristos, Panagiotis; Roth, David B; Aifantis, Iannis; Kluger, Yuval; Deriano, Ludovic; Skok, Jane A
2013 Jul;4:2231-2231, Nature communications
— id: 463612, year: 2013, vol: 4, page: 2231, stat: Journal Article,

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
Guy, Clifford S; Vignali, Kate M; Temirov, Jamshid; Bettini, Matthew L; Overacre, Abigail E; Smeltzer, Matthew; Zhang, Hui; Huppa, Johannes B; Tsai, Yu-Hwai; Lobry, Camille; Xie, Jianming; Dempsey, Peter J; Crawford, Howard C; Aifantis, Iannis; Davis, Mark M; Vignali, Dario A A
2013 Mar;14(3):262-270, Nature immunology
— id: 240732, year: 2013, vol: 14, page: 262, stat: Journal Article,

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability
King, Bryan; Trimarchi, Thomas; Reavie, Linsey; Xu, Luyao; Mullenders, Jasper; Ntziachristos, Panagiotis; Aranda-Orgilles, Beatriz; Perez-Garcia, Arianne; Shi, Junwei; Vakoc, Christopher; Sandy, Peter; Shen, Steven S; Ferrando, Adolfo; Aifantis, Iannis
2013 Jun;153(7):1552-1566, Cell
— id: 402292, year: 2013, vol: 153, page: 1552, stat: Journal Article,

Notch pathway activation targets AML-initiating cell homeostasis and differentiation
Lobry, Camille; Ntziachristos, Panagiotis; Ndiaye-Lobry, Delphine; Oh, Philmo; Cimmino, Luisa; Zhu, Nan; Araldi, Elisa; Hu, Wenhuo; Freund, Jacquelyn; Abdel-Wahab, Omar; Ibrahim, Sherif; Skokos, Dimitris; Armstrong, Scott A; Levine, Ross L; Park, Christopher Y; Aifantis, Iannis
2013 Feb;210(2):301-319, Journal of experimental medicine
— id: 220852, year: 2013, vol: 210, page: 301, stat: Journal Article,

Mechanisms of epigenetic regulation of leukemia onset and progression
Ntziachristos, Panagiotis; Mullenders, Jasper; Trimarchi, Thomas; Aifantis, Iannis
2013 ;117:1-38, Advances in immunology
— id: 305012, year: 2013, vol: 117, page: 1, stat: Journal Article,

In Vivo mapping of notch pathway activity in normal and stress hematopoiesis
Oh, Philmo; Lobry, Camille; Gao, Jie; Tikhonova, Anastasia; Loizou, Evangelia; Manent, Jan; van Handel, Ben; Ibrahim, Sherif; Greve, Jeffrey; Mikkola, Hanna; Artavanis-Tsakonas, Spyros; Aifantis, Iannis
2013 Aug;13(2):190-204, Cell stem cell
— id: 484062, year: 2013, vol: 13, page: 190, stat: Journal Article,

Endothelial jagged-1 is necessary for homeostatic and regenerative hematopoiesis
Poulos, Michael G; Guo, Peipei; Kofler, Natalie M; Pinho, Sandra; Gutkin, Michael C; Tikhonova, Anastasia; Aifantis, Iannis; Frenette, Paul S; Kitajewski, Jan; Rafii, Shahin; Butler, Jason M
2013 Sep;4(5):1022-1034, Cell reports
— id: 557372, year: 2013, vol: 4, page: 1022, stat: Journal Article,

Regulation of c-Myc Ubiquitination Controls Chronic Myelogenous Leukemia Initiation and Progression
Reavie, Linsey; Buckley, Shannon M; Loizou, Evangelia; Takeishi, Shoichiro; Aranda-Orgilles, Beatriz; Ndiaye-Lobry, Delphine; Abdel-Wahab, Omar; Ibrahim, Sherif; Nakayama, Keiichi I; Aifantis, Iannis
2013 Mar;23(3):362-375, Cancer cell
— id: 255272, year: 2013, vol: 23, page: 362, stat: Journal Article,

Epigenetic profiling of leukemia stem cells in a model of TET2/FLT3-mutant AML
Shih, A H; Jiang, Y; Shank, K; Pandey, S; Viale, A; Sun, Y; Socci, N; Robertson, A; De, Stanchina E; Hricik, T; Rapaport, F; Woods, B; Cimmino, L; Barreyro, L; Steidl, U; Aifantis, I; Melnick, A; Levine, R L
2013 21 Oct 2013;122(21):-, Blood
— id: 713112, year: 2013, vol: 122, page: , stat: Journal Article,

A new player SETs in myeloid malignancy
Trimarchi, Thomas; Ntziachristos, Panagiotis; Aifantis, Iannis
2013 Aug;45(8):846-847, Nature genetics
— id: 463592, year: 2013, vol: 45, page: 846, stat: Journal Article,

ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression
Abdel-Wahab, Omar; Adli, Mazhar; Lafave, Lindsay M; Gao, Jie; Hricik, Todd; Shih, Alan H; Pandey, Suveg; Patel, Jay P; Chung, Young Rock; Koche, Richard; Perna, Fabiana; Zhao, Xinyang; Taylor, Jordan E; Park, Christopher Y; Carroll, Martin; Melnick, Ari; Nimer, Stephen D; Jaffe, Jacob D; Aifantis, Iannis; Bernstein, Bradley E; Levine, Ross L
2012 Aug;22(2):180-193, Cancer cell
— id: 177092, year: 2012, vol: 22, page: 180, stat: Journal Article,

Conditional Deletion of Asxl1 Results in Myelodysplasia
Abdel-Wahab, Omar; Gao, Jie; Adli, Mazhar; Chung, Young Rock; Koche, Richard; Shih, Alan H.; Pandey, Suveg; La-Fave, Lindsay M.; Ndiaye-Lobry, Delphine; Shin, Yu Sup; Bhatt, Parva K.; Patel, Jay P.; Zhao, Xinyang; Park, Christopher Y.; Jaffe, Jacob D.; Bernstein, Bradley E.; Aifantis, Iannis; Levine, Ross L.
2012 NOV 16;120(21):-, Blood
— id: 227392, year: 2012, vol: 120, page: , stat: Journal Article,

A Role for TET2 Mutations in Paroxysmal Nocturnal Hemoglobinuria (PNH)
Araten, David J.; Bains, Ashish; Lobry, Camille; Aifantis, Iannis; Ibrahim, Sherif
2012 NOV 16;120(21):-, Blood
— id: 227382, year: 2012, vol: 120, page: , stat: Journal Article,

Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice
Billiard, Fabienne; Lobry, Camille; Darrasse-Jeze, Guillaume; Waite, Janelle; Liu, Xia; Mouquet, Hugo; Danave, Amanda; Tait, Michelle; Idoyaga, Juliana; Leboeuf, Marylene; Kyratsous, Christos A; Burton, Jacquelynn; Kalter, Julie; Klinakis, Apostolos; Zhang, Wen; Thurston, Gavin; Merad, Miriam; Steinman, Ralph M; Murphy, Andrew J; Yancopoulos, George D; Aifantis, Iannis; Skokos, Dimitris
2012 May;209(5):1011-1028, Journal of experimental medicine
— id: 167125, year: 2012, vol: 209, page: 1011, stat: Journal Article,

Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system
Buckley, Shannon M; Aranda-Orgilles, Beatriz; Strikoudis, Alexandros; Apostolou, Effie; Loizou, Evangelia; Moran-Crusio, Kelly; Farnsworth, Charles L; Koller, Antonius A; Dasgupta, Ramanuj; Silva, Jeffrey C; Stadtfeld, Matthias; Hochedlinger, Konrad; Chen, Emily I; Aifantis, Iannis
2012 Dec;11(6):783-798, Cell stem cell
— id: 202132, year: 2012, vol: 11, page: 783, stat: Journal Article,

Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblastic leukemia
Cimmino, Luisa; Aifantis, Iannis
2012 Nov;2(11):976-978, Cancer discovery
— id: 181032, year: 2012, vol: 2, page: 976, stat: Journal Article,

Tet2 Facilitates the Derepression of Myeloid Target Genes during CEBPalpha-Induced Transdifferentiation of Pre-B Cells
Kallin, Eric M; Rodriguez-Ubreva, Javier; Christensen, Jesper; Cimmino, Luisa; Aifantis, Iannis; Helin, Kristian; Ballestar, Esteban; Graf, Thomas
2012 Oct;48(2):266-276, Molecular cell
— id: 184522, year: 2012, vol: 48, page: 266, stat: Journal Article,

Hijacking T Cell Differentiation: New Insights in TLX Function in T-ALL
King, Bryan; Ntziachristos, Panagiotis; Aifantis, Iannis
2012 Apr;21(4):453-455, Cancer cell
— id: 165616, year: 2012, vol: 21, page: 453, stat: Journal Article,

Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system
Moran-Crusio, K; Reavie, LB; Aifantis, I
2012 Feb;:357-363, Trends in immunology
— id: 163325, year: 2012, vol: , page: 357, stat: Journal Article,

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
Ntziachristos, Panagiotis; Tsirigos, Aristotelis; Vlierberghe, Pieter Van; Nedjic, Jelena; Trimarchi, Thomas; Flaherty, Maria Sol; Ferres-Marco, Dolors; da Ros, Vanina; Tang, Zuojian; Siegle, Jasmin; Asp, Patrik; Hadler, Michael; Rigo, Isaura; Keersmaecker, Kim De; Patel, Jay; Huynh, Tien; Utro, Filippo; Poglio, Sandrine; Samon, Jeremy B; Paietta, Elisabeth; Racevskis, Janis; Rowe, Jacob M; Rabadan, Raul; Levine, Ross L; Brown, Stuart; Pflumio, Francoise; Dominguez, Maria; Ferrando, Adolfo; Aifantis, Iannis
2012 ;18(2):298-301, Nature medicine
— id: 158681, year: 2012, vol: 18, page: 298, stat: Journal Article,

Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia
Sawai, Catherine M; Freund, Jacquelyn; Oh, Philmo; Ndiaye-Lobry, Delphine; Bretz, Jamieson C; Strikoudis, Alexandros; Genesca, Lali; Trimarchi, Thomas; Kelliher, Michelle A; Clark, Marcus; Soulier, Jean; Chen-Kiang, Selina; Aifantis, Iannis
2012 Oct;22(4):452-465, Cancer cell
— id: 180642, year: 2012, vol: 22, page: 452, stat: Journal Article,

The Taming of the NF-kappaB: PP4R1 Navigates while PP4c Dephosphorylates
Tikhonova, Anastasia; Aifantis, Iannis
2012 Oct;37(4):594-596, Immunity
— id: 180682, year: 2012, vol: 37, page: 594, stat: Journal Article,

ASXL1 mutations promote myeloid transformation through inhibition of PRC2-mediated gene repression
Abdel-Wahab, O; Adli, M; Saunders, L; Gao, J; Shih, A H; Pandey, S; Jaffe, J; Zhao, X; Perna, F; Carroll, M; Melnick, A; Nimer, S D; Aifantis, I; Bernstein, B; Levine, R L
2011 18 Nov 2011;118(21):-, Blood
— id: 169660, year: 2011, vol: 118, page: , stat: Journal Article,

The notch signaling pathway as a suppressor of myeloid transformation
Aifantis, I
2011 18 Nov 2011;118(21):-, Blood
— id: 169656, year: 2011, vol: 118, page: , stat: Journal Article,

TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation
Cimmino, Luisa; Abdel-Wahab, Omar; Levine, Ross L; Aifantis, Iannis
2011 Sep 2;9(3):193-204, Cell stem cell
— id: 137075, year: 2011, vol: 9, page: 193, stat: Journal Article,

Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia
D'Altri, Teresa; Gonzalez, Jessica; Aifantis, Iannis; Espinosa, Lluis; Bigas, Anna
2011 Apr 1;10(7):1031-1036, Cell cycle
— id: 134230, year: 2011, vol: 10, page: 1031, stat: Journal Article,

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
Germar, Kristine; Dose, Marei; Konstantinou, Tassos; Zhang, Jiangwen; Wang, Hongfang; Lobry, Camille; Arnett, Kelly L; Blacklow, Stephen C; Aifantis, Iannis; Aster, Jon C; Gounari, Fotini
2011 Dec;108(50):20060-20065, Proceedings of the National Academy of Sciences of the United States of America
— id: 163324, year: 2011, vol: 108, page: 20060, stat: Journal Article,

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
Klinakis, Apostolos; Lobry, Camille; Abdel-Wahab, Omar; Oh, Philmo; Haeno, Hiroshi; Buonamici, Silvia; van De Walle, Inge; Cathelin, Severine; Trimarchi, Thomas; Araldi, Elisa; Liu, Cynthia; Ibrahim, Sherif; Beran, Miroslav; Zavadil, Jiri; Efstratiadis, Argiris; Taghon, Tom; Michor, Franziska; Levine, Ross L; Aifantis, Iannis
2011 May 12;473(7346):230-233, Nature
— id: 134267, year: 2011, vol: 473, page: 230, stat: Journal Article,

Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think
Lobry, Camille; Oh, Philmo; Aifantis, Iannis
2011 Sep 26;208(10):1931-1935, Journal of experimental medicine
— id: 137892, year: 2011, vol: 208, page: 1931, stat: Journal Article,

The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis
Mar, B G; Amakye, D; Aifantis, I; Buonamici, S
2011 Nov;25(11):1665-1673, Leukemia
— id: 163326, year: 2011, vol: 25, page: 1665, stat: Journal Article,

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Moran-Crusio, Kelly; Reavie, Linsey; Shih, Alan; Abdel-Wahab, Omar; Ndiaye-Lobry, Delphine; Lobry, Camille; Figueroa, Maria E; Vasanthakumar, Aparna; Patel, Jay; Zhao, Xinyang; Perna, Fabiana; Pandey, Suveg; Madzo, Jozef; Song, Chunxiao; Dai, Qing; He, Chuan; Ibrahim, Sherif; Beran, Miloslav; Zavadil, Jiri; Nimer, Stephen D; Melnick, Ari; Godley, Lucy A; Aifantis, Iannis; Levine, Ross L
2011 Jul 12;20(1):11-24, Cancer cell
— id: 135262, year: 2011, vol: 20, page: 11, stat: Journal Article,

Evaluating clonal dominance in a murine knock-in model of Jak2V617F MPN
Mullally, A; Poveromo, L; Brumme, K; Al-Shahrour, F; Lane, S W; Shih, A H; Aifantis, I; Levine, R L; Ebert, B L
2011 18 Nov 2011;118(21):-, Blood
— id: 169666, year: 2011, vol: 118, page: , stat: Journal Article,

Assessing quality and completeness of human transcriptional regulatory pathways on a genome-wide scale
Shmelkov, Evgeny; Tang, Zuojian; Aifantis, Iannis; Statnikov, Alexander
2011 ;6:15-15, Biology direct
— id: 127234, year: 2011, vol: 6, page: 15, stat: Journal Article,

PHF6 mutations in adult acute myeloid leukemia
Van Vlierberghe, P; Patel, J; Abdel-Wahab, O; Lobry, C; Hedvat, C V; Balbin, M; Nicolas, C; Payer, A R; Fernandez, H F; Tallman, M S; Paietta, E; Melnick, A; Vandenberghe, P; Speleman, F; Aifantis, I; Cools, J; Levine, R; Ferrando, A
2011 Jan;25(1):130-134, Leukemia
— id: 133886, year: 2011, vol: 25, page: 130, stat: Journal Article,

Energy addiction and lymphocyte differentiation: a new role for the liver kinase B1 kinase
Aifantis, Iannis; Sawai, Catherine
2010 Jan;40(1):19-21, European journal of immunology
— id: 106096, year: 2010, vol: 40, page: 19, stat: Journal Article,

The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation
Crusio, K M; King, B; Reavie, L B; Aifantis, I
2010 Sep 2;29(35):4865-4873, Oncogene
— id: 112034, year: 2010, vol: 29, page: 4865, stat: Journal Article,

The Notch/Hes1 pathway sustains NF-kappaB activation through CYLD repression in T cell leukemia
Espinosa, Lluis; Cathelin, Severine; D'Altri, Teresa; Trimarchi, Thomas; Statnikov, Alexander; Guiu, Jordi; Rodilla, Veronica; Ingles-Esteve, Julia; Nomdedeu, Josep; Bellosillo, Beatriz; Besses, Carles; Abdel-Wahab, Omar; Kucine, Nicole; Sun, Shao-Cong; Song, Guangchan; Mullighan, Charles C; Levine, Ross L; Rajewsky, Klaus; Aifantis, Iannis; Bigas, Anna
2010 Sep 14;18(3):268-281, Cancer cell
— id: 133795, year: 2010, vol: 18, page: 268, stat: Journal Article,

RNA-binding proteins come out of the shadows
Nedjic, Jelena; Aifantis, Iannis
2010 Aug;11(8):697-698, Nature immunology
— id: 111392, year: 2010, vol: 11, page: 697, stat: Journal Article,

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex
Reavie, Linsey; Della Gatta, Giusy; Crusio, Kelly; Aranda-Orgilles, Beatriz; Buckley, Shannon M; Thompson, Benjamin; Lee, Eugine; Gao, Jie; Bredemeyer, Andrea L; Helmink, Beth A; Zavadil, Jiri; Sleckman, Barry P; Palomero, Teresa; Ferrando, Adolfo; Aifantis, Iannis
2010 Mar;11(3):207-215, Nature immunology
— id: 159179, year: 2010, vol: 11, page: 207, stat: Journal Article,

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
Buonamici, Silvia; Trimarchi, Thomas; Ruocco, Maria Grazia; Reavie, Linsey; Cathelin, Severine; Mar, Brenton G; Klinakis, Apostolos; Lukyanov, Yevgeniy; Tseng, Jen-Chieh; Sen, Filiz; Gehrie, Eric; Li, Mengling; Newcomb, Elizabeth; Zavadil, Jiri; Meruelo, Daniel; Lipp, Martin; Ibrahim, Sherif; Efstratiadis, Argiris; Zagzag, David; Bromberg, Jonathan S; Dustin, Michael L; Aifantis, Iannis
2009 Jun 18;459(7249):1000-1004, Nature
— id: 105354, year: 2009, vol: 459, page: 1000, stat: Journal Article,

Hedgehog and hematopoietic stem cell differentiation Don't believe the hype!
Gao, J; Aifantis, I
2009 DEC 1 ;8(23):3789-3790, Cell cycle
— id: 105637, year: 2009, vol: 8, page: 3789, stat: Journal Article,

Hedgehog and hematopoietic stem cell differentiation: don't believe the hype!
Gao, Jie; Aifantis, Iannis
2009 Dec;8(23):3789-3790, Cell cycle
— id: 163327, year: 2009, vol: 8, page: 3789, stat: Journal Article,

Hedgehog signaling is dispensable for adult hematopoietic stem cell function
Gao, Jie; Graves, Stephanie; Koch, Ute; Liu, Suqing; Jankovic, Vladimir; Buonamici, Silvia; El Andaloussi, Abdeljabar; Nimer, Stephen D; Kee, Barbara L; Taichman, Russell; Radtke, Freddy; Aifantis, Iannis
2009 Jun 5;4(6):548-558, Cell stem cell
— id: 99328, year: 2009, vol: 4, page: 548, stat: Journal Article,

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Real, Pedro J; Tosello, Valeria; Palomero, Teresa; Castillo, Mireia; Hernando, Eva; de Stanchina, Elisa; Sulis, Maria Luisa; Barnes, Kelly; Sawai, Catherine; Homminga, Irene; Meijerink, Jules; Aifantis, Iannis; Basso, Giuseppe; Cordon-Cardo, Carlos; Ai, Walden; Ferrando, Adolfo
2009 Jan;15(1):50-58, Nature medicine
— id: 105355, year: 2009, vol: 15, page: 50, stat: Journal Article,

Molecular pathogenesis of T-cell leukaemia and lymphoma
Aifantis, Iannis; Raetz, Elizabeth; Buonamici, Silvia
2008 May;8(5):380-390, Nature reviews. Immunology
— id: 79384, year: 2008, vol: 8, page: 380, stat: Journal Article,

Knockdown of CCR7 or Its Ligands Causes a Loss of Central Nervous System Involvement in Notch1 Induced T-ALL
Buonamici, S; Trimarchi, T; Klinakis, A; Reavie, L; Mar, BG; Gehrie, E; Kuan, EL; Randolph, GJ; Bromberg, J; Aifantis, I
2008 NOV 16 ;112(11):81-81, Blood
— id: 93280, year: 2008, vol: 112, page: 81, stat: Journal Article,

Hexamethylene bisacetamide as a treatment for T-cell leukemia (T-ALL)
Buonamici, Silvia; Aifantis, Iannis
2008 May;32(5):689-690, Leukemia research
— id: 81332, year: 2008, vol: 32, page: 689, stat: Journal Article,

Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
Johnson, Kristen; Hashimshony, Tamar; Sawai, Catherine M; Pongubala, Jagan M R; Skok, Jane A; Aifantis, Iannis; Singh, Harinder
2008 Mar;28(3):335-345, Immunity
— id: 81074, year: 2008, vol: 28, page: 335, stat: Journal Article,

Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid
Mandal, Malay; Crusio, Kelly M; Meng, Fanyong; Liu, Suqing; Kinsella, Marcus; Clark, Marcus R; Takeuchi, Osamu; Aifantis, Iannis
2008 Dec 30;105(52):20840-20845, Proceedings of the National Academy of Sciences of the United States of America
— id: 105356, year: 2008, vol: 105, page: 20840, stat: Journal Article,

Inhibition of NOTCH1 Signaling and Glucocorticoid Therapy in T-ALL
Real, PJ; Tosello, V; Palomero, T; Castillo, M; Sawai, C; Sulis, ML; Meijerink, JPP; Basso, G; Aifantis, I; Cordon-Cardo, C; Ferrando, AA
2008 NOV 16 ;112(11):116-116, Blood
— id: 93281, year: 2008, vol: 112, page: 116, stat: Journal Article,

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
Thompson, Benjamin J; Jankovic, Vladimir; Gao, Jie; Buonamici, Silvia; Vest, Alan; Lee, Jennifer May; Zavadil, Jiri; Nimer, Stephen D; Aifantis, Iannis
2008 Jun 9;205(6):1395-1408, Journal of experimental medicine
— id: 79221, year: 2008, vol: 205, page: 1395, stat: Journal Article,

The Effect of Ubiquitination on Hematopoietic Stem Cell Differentiation and Transformation
Aifantis, Iannis
[S.l.] : NIH, 2007,
— id: 1431, year: 2007, vol: , page: , stat: ,

Notches, NFkappaBs and the making of T cell leukemia
Aifantis, Iannis; Vilimas, Tomas; Buonamici, Silvia
2007 Feb;6(4):403-406, Cell cycle
— id: 71422, year: 2007, vol: 6, page: 403, stat: Journal Article,

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Thompson, Benjamin J; Buonamici, Silvia; Sulis, Maria Luisa; Palomero, Teresa; Vilimas, Tomas; Basso, Giuseppe; Ferrando, Adolfo; Aifantis, Iannis
2007 Aug 6;204(8):1825-1835, Journal of experimental medicine
— id: 73913, year: 2007, vol: 204, page: 1825, stat: Journal Article,

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
Vilimas, Tomas; Mascarenhas, Joaquina; Palomero, Teresa; Mandal, Malay; Buonamici, Silvia; Meng, Fanyong; Thompson, Benjamin; Spaulding, Christina; Macaroun, Sami; Alegre, Maria-Luisa; Kee, Barbara L; Ferrando, Adolfo; Miele, Lucio; Aifantis, Iannis
2007 Jan;13(1):70-77, Nature medicine
— id: 69487, year: 2007, vol: 13, page: 70, stat: Journal Article,

The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells
Aifantis, Iannis; Bassing, Craig H; Garbe, Annette I; Sawai, Katie; Alt, Frederick W; von Boehmer, Harald
2006 Jun 12;203(6):1543-1550, Journal of experimental medicine
— id: 68860, year: 2006, vol: 203, page: 1543, stat: Journal Article,

Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor
Aifantis, Iannis; Mandal, Malay; Sawai, Katie; Ferrando, Adolfo; Vilimas, Tomas
2006 Feb;209:159-169, Immunological reviews
— id: 68866, year: 2006, vol: 209, page: 159, stat: Journal Article,

A unique function for cyclin D3 in early B cell development
Cooper, A Byron; Sawai, Catherine M; Sicinska, Ewa; Powers, Sarah E; Sicinski, Piotr; Clark, Marcus R; Aifantis, Iannis
2006 May;7(5):489-497, Nature immunology
— id: 68862, year: 2006, vol: 7, page: 489, stat: Journal Article,

Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus
El Andaloussi, Abdeljabar; Graves, Stephanie; Meng, Fanyong; Mandal, Malay; Mashayekhi, Mona; Aifantis, Iannis
2006 Apr;7(4):418-426, Nature immunology
— id: 68863, year: 2006, vol: 7, page: 418, stat: Journal Article,

Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms
Reschly, Erica J; Spaulding, Christina; Vilimas, Tomas; Graham, W Vallen; Brumbaugh, Rachel L; Aifantis, Iannis; Pear, Warren S; Kee, Barbara L
2006 May 15;107(10):4115-4121, Blood
— id: 68865, year: 2006, vol: 107, page: 4115, stat: Journal Article,

A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus
Scimone, M Lucila; Aifantis, Iannis; Apostolou, Irina; von Boehmer, Harald; von Andrian, Ulrich H
2006 May 2;103(18):7006-7011, Proceedings of the National Academy of Sciences of the United States of America
— id: 68861, year: 2006, vol: 103, page: 7006, stat: Journal Article,

The pre-B cell receptor in B cell development: recent advances, persistent questions and conserved mechanisms
Clark, M R; Cooper, A B; Wang, L D; Aifantis, I
2005 ;290:87-103, Current topics in microbiology & immunology
— id: 68864, year: 2005, vol: 290, page: 87, stat: Journal Article,

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
Mandal, Malay; Borowski, Christine; Palomero, Teresa; Ferrando, Adolfo A; Oberdoerffer, Philipp; Meng, Fanyong; Ruiz-Vela, Antonio; Ciofani, Maria; Zuniga-Pflucker, Juan-Carlos; Screpanti, Isabella; Look, A Thomas; Korsmeyer, Stanley J; Rajewsky, Klaus; von Boehmer, Harald; Aifantis, Iannis
2005 Feb 21;201(4):603-614, Journal of experimental medicine
— id: 68868, year: 2005, vol: 201, page: 603, stat: Journal Article,

Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages
Oberdoerffer, Philipp; Kanellopoulou, Chryssa; Heissmeyer, Vigo; Paeper, Corinna; Borowski, Christine; Aifantis, Iannis; Rao, Anjana; Rajewsky, Klaus
2005 May;25(10):3896-3905, Molecular & cellular biology
— id: 68867, year: 2005, vol: 25, page: 3896, stat: Journal Article,

Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development
Borowski, Christine; Li, Xiaoyan; Aifantis, Iannis; Gounari, Fotini; von Boehmer, Harald
2004 Mar 1;199(5):607-615, Journal of experimental medicine
— id: 68869, year: 2004, vol: 199, page: 607, stat: Journal Article,

Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential
Martin, Colin H; Aifantis, Iannis; Scimone, M Lucila; von Andrian, Ulrich H; Reizis, Boris; von Boehmer, Harald; Gounari, Fotini
2003 Sep;4(9):866-873, Nature immunology
— id: 68871, year: 2003, vol: 4, page: 866, stat: Journal Article,

Requirement for cyclin D3 in lymphocyte development and T cell leukemias
Sicinska, Ewa; Aifantis, Iannis; Le Cam, Laurent; Swat, Wojciech; Borowski, Christine; Yu, Qunyan; Ferrando, Adolfo A; Levin, Steven D; Geng, Yan; von Boehmer, Harald; Sicinski, Piotr
2003 Dec;4(6):451-461, Cancer cell
— id: 68870, year: 2003, vol: 4, page: 451, stat: Journal Article,

Thymic selection revisited: how essential is it?
von Boehmer, Harald; Aifantis, Iannis; Gounari, Fotini; Azogui, Orly; Haughn, Loralee; Apostolou, Irina; Jaeckel, Elmar; Grassi, Fabio; Klein, Ludger
2003 Feb;191:62-78, Immunological reviews
— id: 68872, year: 2003, vol: 191, page: 62, stat: Journal Article,

A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development
Aifantis, Iannis; Borowski, Christine; Gounari, Fotini; Lacorazza, H Daniel; Nikolich-Zugich, Janko; von Boehmer, Harald
2002 May;3(5):483-488, Nature immunology
— id: 68874, year: 2002, vol: 3, page: 483, stat: Journal Article,

On the brink of becoming a T cell
Borowski, Christine; Martin, Colin; Gounari, Fotini; Haughn, Loralee; Aifantis, Iannis; Grassi, Fabio; von Boehmer, Harald
2002 Apr;14(2):200-206, Current opinion in immunology
— id: 68876, year: 2002, vol: 14, page: 200, stat: Journal Article,

Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene
Gounari, Fotini; Aifantis, Iannis; Martin, Colin; Fehling, Hans-Joerg; Hoeflinger, Sonja; Leder, Philip; von Boehmer, Harald; Reizis, Boris
2002 May;3(5):489-496, Nature immunology
— id: 68875, year: 2002, vol: 3, page: 489, stat: Journal Article,

Positive selection by the pre-TCR yields mature CD8+ T cells
Ito, Yuriko; Arai, Satoko; van Oers, Nicolai S C; Aifantis, Iannis; von Boehmer, Harald; Miyazaki, Toru
2002 Nov 1;169(9):4913-4919, Journal of immunology
— id: 68873, year: 2002, vol: 169, page: 4913, stat: Journal Article,

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT
Aifantis, I; Gounari, F; Scorrano, L; Borowski, C; von Boehmer, H
2001 May;2(5):403-409, Nature immunology
— id: 68878, year: 2001, vol: 2, page: 403, stat: Journal Article,

Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development
Gounari, F; Aifantis, I; Khazaie, K; Hoeflinger, S; Harada, N; Taketo, M M; von Boehmer, H
2001 Sep;2(9):863-869, Nature immunology
— id: 68877, year: 2001, vol: 2, page: 863, stat: Journal Article,

Nitric oxide production by pre-implantation embryos in response to embryotoxic factors
Athanassakis, I; Aifantis, I; Baritakis, S; Farmakiotis, V; Koumantakis, E; Vassiliadis, S
2000 ;10(3):169-176, Cellular physiology & biochemistry
— id: 68880, year: 2000, vol: 10, page: 169, stat: Journal Article,

Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex
Aifantis, I; Feinberg, J; Fehling, H J; Di Santo, J P; von Boehmer, H
1999 Jul 5;190(1):141-144, Journal of experimental medicine
— id: 68884, year: 1999, vol: 190, page: 141, stat: Journal Article,

Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein
Aifantis, I; Pivniouk, V I; Gartner, F; Feinberg, J; Swat, W; Alt, F W; von Boehmer, H; Geha, R S
1999 Oct 18;190(8):1093-1102, Journal of experimental medicine
— id: 68882, year: 1999, vol: 190, page: 1093, stat: Journal Article,

Inhibition of nitric oxide production rescues LPS-induced fetal abortion in mice
Athanassakis, I; Aifantis, I; Ranella, A; Giouremou, K; Vassiliadis, S
1999 Jun;3(3):216-224, Nitric oxide : biology & chemistry
— id: 68883, year: 1999, vol: 3, page: 216, stat: Journal Article,

Expression of corticotrophin-releasing hormone in the mouse uterus: participation in embryo implantation
Athanassakis, I; Farmakiotis, V; Aifantis, I; Gravanis, A; Vassiliadis, S
1999 Nov;163(2):221-227, Journal of endocrinology
— id: 68881, year: 1999, vol: 163, page: 221, stat: Journal Article,

The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development
Di Santo, J P; Aifantis, I; Rosmaraki, E; Garcia, C; Feinberg, J; Fehling, H J; Fischer, A; von Boehmer, H; Rocha, B
1999 Feb 1;189(3):563-574, Journal of experimental medicine
— id: 68886, year: 1999, vol: 189, page: 563, stat: Journal Article,

The impact of pre-T-cell receptor signals on gene expression in developing T cells
von Boehmer, H; Aifantis, I; Azogui, O; Saint-Ruf, C; Grassi, F
1999 ;64:283-289, Cold Spring Harbor symposia on quantitative biology
— id: 68879, year: 1999, vol: 64, page: 283, stat: Journal Article,

Pleiotropic changes controlled by the pre-T-cell receptor
von Boehmer, H; Aifantis, I; Feinberg, J; Lechner, O; Saint-Ruf, C; Walter, U; Buer, J; Azogui, O
1999 Apr;11(2):135-142, Current opinion in immunology
— id: 68885, year: 1999, vol: 11, page: 135, stat: Journal Article,

On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment
Aifantis, I; Azogui, O; Feinberg, J; Saint-Ruf, C; Buer, J; von Boehmer, H
1998 Nov;9(5):649-655, Immunity
— id: 68888, year: 1998, vol: 9, page: 649, stat: Journal Article,

Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment
von Boehmer, H; Aifantis, I; Azogui, O; Feinberg, J; Saint-Ruf, C; Zober, C; Garcia, C; Buer, J
1998 Oct;165:111-119, Immunological reviews
— id: 68887, year: 1998, vol: 165, page: 111, stat: Journal Article,

Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus
Aifantis, I; Buer, J; von Boehmer, H; Azogui, O
1997 Nov;7(5):601-607, Immunity
— id: 68889, year: 1997, vol: 7, page: 601, stat: Journal Article,

Role of different T cell receptors in the development of pre-T cells
Buer, J; Aifantis, I; DiSanto, J P; Fehling, H J; von Boehmer, H
1997 May 5;185(9):1541-1547, Journal of experimental medicine
— id: 68891, year: 1997, vol: 185, page: 1541, stat: Journal Article,

T-cell development in the absence of the pre-T-cell receptor
Buer, J; Aifantis, I; DiSanto, J P; Fehling, H J; von Boehmer, H
1997 Jun 1;57(1-3):5-8, Immunology letters
— id: 68890, year: 1997, vol: 57, page: 5, stat: Journal Article,