Ioannis Aifantis

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Ioannis Aifantis, Ph.D.

Professor; Chair of the Department of Pathology
Department of Pathology (Pathology)

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Education

1994-1996 — Masters in Science, "Molecular Biology and Genetics", University of Crete, Greece, Graduate Education
1996-1999 — Ph.D., "Immunology", University of Paris V, France, Graduate Education
1999-2003 — Harvard Medical School (Dana Farber Cancer Institute), USA, PostDoctoral Training

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Research Interests

Our laboratory studies the molecular mechanisms controlling hematopoietic stem cell (HSC) self-renewal, differentiation and transformation. More specifically we focus on the regulation of HSC cell cycle entry and on the effects of Notch signaling in stem cell differentiation. Finally, we study the role of the Notch pathway as an oncogenic trigger in acute lymphoblastic leukemia. Our goal is to design novel therapies that will target and suppress Notch transforming activity in vivo.

Research Documents

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All data from NYU Health Sciences Library Faculty Bibliography — -

Contact:
http://hsl.med.nyu.edu/faculty-bibliography-search

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes
Di Micco, Raffaella; Fontanals-Cirera, Barbara; Low, Vivien; Ntziachristos, Panagiotis; Yuen, Stephanie K; Lovell, Claudia D; Dolgalev, Igor; Yonekubo, Yoshiya; Zhang, Guangtao; Rusinova, Elena; Gerona-Navarro, Guillermo; Canamero, Marta; Ohlmeyer, Michael; Aifantis, Iannis; Zhou, Ming-Ming; Tsirigos, Aristotelis; Hernando, Eva
2014 Sep;:e1-e63, Cell reports
— id: 1259942, year: 2014, vol: , page: e1, stat: Journal Article,

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation
Gough, Daniel J; Marie, Isabelle J; Lobry, Camille; Aifantis, Iannis; Levy, David E
2014 Oct;124(14):2252-2261, Blood
— id: 1298802, year: 2014, vol: 124, page: 2252, stat: Journal Article,

Cyclin C is a haploinsufficient tumour suppressor
Li, Na; Fassl, Anne; Chick, Joel; Inuzuka, Hiroyuki; Li, Xiaoyu; Mansour, Marc R; Liu, Lijun; Wang, Haizhen; King, Bryan; Shaik, Shavali; Gutierrez, Alejandro; Ordureau, Alban; Otto, Tobias; Kreslavsky, Taras; Baitsch, Lukas; Bury, Leah; Meyer, Clifford A; Ke, Nan; Mulry, Kristin A; Kluk, Michael J; Roy, Moni; Kim, Sunkyu; Zhang, Xiaowu; Geng, Yan; Zagozdzon, Agnieszka; Jenkinson, Sarah; Gale, Rosemary E; Linch, David C; Zhao, Jean J; Mullighan, Charles G; Harper, J Wade; Aster, Jon C; Aifantis, Iannis; von Boehmer, Harald; Gygi, Steven P; Wei, Wenyi; Look, A Thomas; Sicinski, Piotr
2014 Nov;16(11):1080-1091, Nature cell biology
— id: 1341862, year: 2014, vol: 16, page: 1080, stat: Journal Article,

Notch signaling: switching an oncogene to a tumor suppressor
Lobry, Camille; Oh, Philmo; Mansour, Marc R; Look, A Thomas; Aifantis, Iannis
2014 Apr;123(16):2451-2459, Blood
— id: 917732, year: 2014, vol: 123, page: 2451, stat: Journal Article,

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling
Ntziachristos, Panagiotis; Lim, Jing Shan; Sage, Julien; Aifantis, Iannis
2014 Mar;25(3):318-334, Cancer cell
— id: 868002, year: 2014, vol: 25, page: 318, stat: Journal Article,

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
Ntziachristos, Panagiotis; Tsirigos, Aristotelis; Welstead, G Grant; Trimarchi, Thomas; Bakogianni, Sofia; Xu, Luyao; Loizou, Evangelia; Holmfeldt, Linda; Strikoudis, Alexandros; King, Bryan; Mullanders, Jasper; Becksfort, Jared; Nedjic, Jelena; Paietta, Elisabeth; Tallman, Martin S; Rowe, Jacob M; Tonon, Giovanni; Satoh, Takashi; Kruidenier, Laurens; Prinjha, Rab; Akira, Shizuo; Van Vlierberghe, Pieter; Ferrando, Adolfo A; Jaenisch, Rudolf; Mullighan, Charles G; Aifantis, Iannis
2014 Aug;:1243-1244, Nature
— id: 1142252, year: 2014, vol: , page: 1243, stat: Journal Article,

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast
Rustighi, Alessandra; Zannini, Alessandro; Tiberi, Luca; Sommaggio, Roberta; Piazza, Silvano; Sorrentino, Giovanni; Nuzzo, Simona; Tuscano, Antonella; Eterno, Vincenzo; Benvenuti, Federica; Santarpia, Libero; Aifantis, Iannis; Rosato, Antonio; Bicciato, Silvio; Zambelli, Alberto; Del Sal, Giannino
2014 Jan;6(1):99-119, EMBO molecular medicine
— id: 781732, year: 2014, vol: 6, page: 99, stat: Journal Article,

Regulation of stem cell function by protein ubiquitylation
Strikoudis, Alexandros; Guillamot, Maria; Aifantis, Iannis
2014 Apr;15(4):365-382, EMBO reports
— id: 867132, year: 2014, vol: 15, page: 365, stat: Journal Article,

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia
Trimarchi, Thomas; Bilal, Erhan; Ntziachristos, Panagiotis; Fabbri, Giulia; Dalla-Favera, Riccardo; Tsirigos, Aristotelis; Aifantis, Iannis
2014 Jul;158(3):593-606, Cell
— id: 1090482, year: 2014, vol: 158, page: 593, stat: Journal Article,

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Abdel-Wahab, Omar; Gao, Jie; Adli, Mazhar; Dey, Anwesha; Trimarchi, Thomas; Chung, Young Rock; Kuscu, Cem; Hricik, Todd; Ndiaye-Lobry, Delphine; Lafave, Lindsay M; Koche, Richard; Shih, Alan H; Guryanova, Olga A; Kim, Eunhee; Li, Sheng; Pandey, Suveg; Shin, Joseph Y; Telis, Leon; Liu, Jinfeng; Bhatt, Parva K; Monette, Sebastien; Zhao, Xinyang; Mason, Christopher E; Park, Christopher Y; Bernstein, Bradley E; Aifantis, Iannis; Levine, Ross L
2013 Nov;210(12):2641-2659, Journal of experimental medicine
— id: 687442, year: 2013, vol: 210, page: 2641, stat: Journal Article,

Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers
Chaumeil, Julie; Micsinai, Mariann; Ntziachristos, Panagiotis; Deriano, Ludovic; Wang, Joy M-H; Ji, Yanhong; Nora, Elphege P; Rodesch, Matthew J; Jeddeloh, Jeffrey A; Aifantis, Iannis; Kluger, Yuval; Schatz, David G; Skok, Jane A
2013 Feb;3(2):359-370, Cell reports
— id: 242262, year: 2013, vol: 3, page: 359, stat: Journal Article,

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage
Chaumeil, Julie; Micsinai, Mariann; Ntziachristos, Panagiotis; Roth, David B; Aifantis, Iannis; Kluger, Yuval; Deriano, Ludovic; Skok, Jane A
2013 Jul;4:2231-2231, Nature communications
— id: 463612, year: 2013, vol: 4, page: 2231, stat: Journal Article,

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
Guy, Clifford S; Vignali, Kate M; Temirov, Jamshid; Bettini, Matthew L; Overacre, Abigail E; Smeltzer, Matthew; Zhang, Hui; Huppa, Johannes B; Tsai, Yu-Hwai; Lobry, Camille; Xie, Jianming; Dempsey, Peter J; Crawford, Howard C; Aifantis, Iannis; Davis, Mark M; Vignali, Dario A A
2013 Mar;14(3):262-270, Nature immunology
— id: 240732, year: 2013, vol: 14, page: 262, stat: Journal Article,

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability
King, Bryan; Trimarchi, Thomas; Reavie, Linsey; Xu, Luyao; Mullenders, Jasper; Ntziachristos, Panagiotis; Aranda-Orgilles, Beatriz; Perez-Garcia, Arianne; Shi, Junwei; Vakoc, Christopher; Sandy, Peter; Shen, Steven S; Ferrando, Adolfo; Aifantis, Iannis
2013 Jun;153(7):1552-1566, Cell
— id: 402292, year: 2013, vol: 153, page: 1552, stat: Journal Article,

Notch pathway activation targets AML-initiating cell homeostasis and differentiation
Lobry, Camille; Ntziachristos, Panagiotis; Ndiaye-Lobry, Delphine; Oh, Philmo; Cimmino, Luisa; Zhu, Nan; Araldi, Elisa; Hu, Wenhuo; Freund, Jacquelyn; Abdel-Wahab, Omar; Ibrahim, Sherif; Skokos, Dimitris; Armstrong, Scott A; Levine, Ross L; Park, Christopher Y; Aifantis, Iannis
2013 Feb;210(2):301-319, Journal of experimental medicine
— id: 220852, year: 2013, vol: 210, page: 301, stat: Journal Article,

Mechanisms of epigenetic regulation of leukemia onset and progression
Ntziachristos, Panagiotis; Mullenders, Jasper; Trimarchi, Thomas; Aifantis, Iannis
2013 ;117:1-38, Advances in immunology
— id: 305012, year: 2013, vol: 117, page: 1, stat: Journal Article,

In Vivo mapping of notch pathway activity in normal and stress hematopoiesis
Oh, Philmo; Lobry, Camille; Gao, Jie; Tikhonova, Anastasia; Loizou, Evangelia; Manent, Jan; van Handel, Ben; Ibrahim, Sherif; Greve, Jeffrey; Mikkola, Hanna; Artavanis-Tsakonas, Spyros; Aifantis, Iannis
2013 Aug;13(2):190-204, Cell stem cell
— id: 484062, year: 2013, vol: 13, page: 190, stat: Journal Article,

Endothelial jagged-1 is necessary for homeostatic and regenerative hematopoiesis
Poulos, Michael G; Guo, Peipei; Kofler, Natalie M; Pinho, Sandra; Gutkin, Michael C; Tikhonova, Anastasia; Aifantis, Iannis; Frenette, Paul S; Kitajewski, Jan; Rafii, Shahin; Butler, Jason M
2013 Sep;4(5):1022-1034, Cell reports
— id: 557372, year: 2013, vol: 4, page: 1022, stat: Journal Article,

Regulation of c-Myc Ubiquitination Controls Chronic Myelogenous Leukemia Initiation and Progression
Reavie, Linsey; Buckley, Shannon M; Loizou, Evangelia; Takeishi, Shoichiro; Aranda-Orgilles, Beatriz; Ndiaye-Lobry, Delphine; Abdel-Wahab, Omar; Ibrahim, Sherif; Nakayama, Keiichi I; Aifantis, Iannis
2013 Mar;23(3):362-375, Cancer cell
— id: 255272, year: 2013, vol: 23, page: 362, stat: Journal Article,

Epigenetic profiling of leukemia stem cells in a model of TET2/FLT3-mutant AML
Shih, A H; Jiang, Y; Shank, K; Pandey, S; Viale, A; Sun, Y; Socci, N; Robertson, A; De, Stanchina E; Hricik, T; Rapaport, F; Woods, B; Cimmino, L; Barreyro, L; Steidl, U; Aifantis, I; Melnick, A; Levine, R L
2013 21 Oct 2013;122(21):-, Blood
— id: 713112, year: 2013, vol: 122, page: , stat: Journal Article,

A new player SETs in myeloid malignancy
Trimarchi, Thomas; Ntziachristos, Panagiotis; Aifantis, Iannis
2013 Aug;45(8):846-847, Nature genetics
— id: 463592, year: 2013, vol: 45, page: 846, stat: Journal Article,

ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression
Abdel-Wahab, Omar; Adli, Mazhar; Lafave, Lindsay M; Gao, Jie; Hricik, Todd; Shih, Alan H; Pandey, Suveg; Patel, Jay P; Chung, Young Rock; Koche, Richard; Perna, Fabiana; Zhao, Xinyang; Taylor, Jordan E; Park, Christopher Y; Carroll, Martin; Melnick, Ari; Nimer, Stephen D; Jaffe, Jacob D; Aifantis, Iannis; Bernstein, Bradley E; Levine, Ross L
2012 Aug;22(2):180-193, Cancer cell
— id: 177092, year: 2012, vol: 22, page: 180, stat: Journal Article,

Conditional Deletion of Asxl1 Results in Myelodysplasia
Abdel-Wahab, Omar; Gao, Jie; Adli, Mazhar; Chung, Young Rock; Koche, Richard; Shih, Alan H.; Pandey, Suveg; La-Fave, Lindsay M.; Ndiaye-Lobry, Delphine; Shin, Yu Sup; Bhatt, Parva K.; Patel, Jay P.; Zhao, Xinyang; Park, Christopher Y.; Jaffe, Jacob D.; Bernstein, Bradley E.; Aifantis, Iannis; Levine, Ross L.
2012 NOV 16;120(21):-, Blood
— id: 227392, year: 2012, vol: 120, page: , stat: Journal Article,

A Role for TET2 Mutations in Paroxysmal Nocturnal Hemoglobinuria (PNH)
Araten, David J.; Bains, Ashish; Lobry, Camille; Aifantis, Iannis; Ibrahim, Sherif
2012 NOV 16;120(21):-, Blood
— id: 227382, year: 2012, vol: 120, page: , stat: Journal Article,

Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice
Billiard, Fabienne; Lobry, Camille; Darrasse-Jeze, Guillaume; Waite, Janelle; Liu, Xia; Mouquet, Hugo; Danave, Amanda; Tait, Michelle; Idoyaga, Juliana; Leboeuf, Marylene; Kyratsous, Christos A; Burton, Jacquelynn; Kalter, Julie; Klinakis, Apostolos; Zhang, Wen; Thurston, Gavin; Merad, Miriam; Steinman, Ralph M; Murphy, Andrew J; Yancopoulos, George D; Aifantis, Iannis; Skokos, Dimitris
2012 May;209(5):1011-1028, Journal of experimental medicine
— id: 167125, year: 2012, vol: 209, page: 1011, stat: Journal Article,

Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system
Buckley, Shannon M; Aranda-Orgilles, Beatriz; Strikoudis, Alexandros; Apostolou, Effie; Loizou, Evangelia; Moran-Crusio, Kelly; Farnsworth, Charles L; Koller, Antonius A; Dasgupta, Ramanuj; Silva, Jeffrey C; Stadtfeld, Matthias; Hochedlinger, Konrad; Chen, Emily I; Aifantis, Iannis
2012 Dec;11(6):783-798, Cell stem cell
— id: 202132, year: 2012, vol: 11, page: 783, stat: Journal Article,

Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblastic leukemia
Cimmino, Luisa; Aifantis, Iannis
2012 Nov;2(11):976-978, Cancer discovery
— id: 181032, year: 2012, vol: 2, page: 976, stat: Journal Article,

Tet2 Facilitates the Derepression of Myeloid Target Genes during CEBPalpha-Induced Transdifferentiation of Pre-B Cells
Kallin, Eric M; Rodriguez-Ubreva, Javier; Christensen, Jesper; Cimmino, Luisa; Aifantis, Iannis; Helin, Kristian; Ballestar, Esteban; Graf, Thomas
2012 Oct;48(2):266-276, Molecular cell
— id: 184522, year: 2012, vol: 48, page: 266, stat: Journal Article,

Hijacking T Cell Differentiation: New Insights in TLX Function in T-ALL
King, Bryan; Ntziachristos, Panagiotis; Aifantis, Iannis
2012 Apr;21(4):453-455, Cancer cell
— id: 165616, year: 2012, vol: 21, page: 453, stat: Journal Article,

Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system
Moran-Crusio, K; Reavie, LB; Aifantis, I
2012 Feb;:357-363, Trends in immunology
— id: 163325, year: 2012, vol: , page: 357, stat: Journal Article,

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
Ntziachristos, Panagiotis; Tsirigos, Aristotelis; Vlierberghe, Pieter Van; Nedjic, Jelena; Trimarchi, Thomas; Flaherty, Maria Sol; Ferres-Marco, Dolors; da Ros, Vanina; Tang, Zuojian; Siegle, Jasmin; Asp, Patrik; Hadler, Michael; Rigo, Isaura; Keersmaecker, Kim De; Patel, Jay; Huynh, Tien; Utro, Filippo; Poglio, Sandrine; Samon, Jeremy B; Paietta, Elisabeth; Racevskis, Janis; Rowe, Jacob M; Rabadan, Raul; Levine, Ross L; Brown, Stuart; Pflumio, Francoise; Dominguez, Maria; Ferrando, Adolfo; Aifantis, Iannis
2012 ;18(2):298-301, Nature medicine
— id: 158681, year: 2012, vol: 18, page: 298, stat: Journal Article,

Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia
Sawai, Catherine M; Freund, Jacquelyn; Oh, Philmo; Ndiaye-Lobry, Delphine; Bretz, Jamieson C; Strikoudis, Alexandros; Genesca, Lali; Trimarchi, Thomas; Kelliher, Michelle A; Clark, Marcus; Soulier, Jean; Chen-Kiang, Selina; Aifantis, Iannis
2012 Oct;22(4):452-465, Cancer cell
— id: 180642, year: 2012, vol: 22, page: 452, stat: Journal Article,

The Taming of the NF-kappaB: PP4R1 Navigates while PP4c Dephosphorylates
Tikhonova, Anastasia; Aifantis, Iannis
2012 Oct;37(4):594-596, Immunity
— id: 180682, year: 2012, vol: 37, page: 594, stat: Journal Article,

ASXL1 mutations promote myeloid transformation through inhibition of PRC2-mediated gene repression
Abdel-Wahab, O; Adli, M; Saunders, L; Gao, J; Shih, A H; Pandey, S; Jaffe, J; Zhao, X; Perna, F; Carroll, M; Melnick, A; Nimer, S D; Aifantis, I; Bernstein, B; Levine, R L
2011 18 Nov 2011;118(21):-, Blood
— id: 169660, year: 2011, vol: 118, page: , stat: Journal Article,

The notch signaling pathway as a suppressor of myeloid transformation
Aifantis, I
2011 18 Nov 2011;118(21):-, Blood
— id: 169656, year: 2011, vol: 118, page: , stat: Journal Article,

TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation
Cimmino, Luisa; Abdel-Wahab, Omar; Levine, Ross L; Aifantis, Iannis
2011 Sep 2;9(3):193-204, Cell stem cell
— id: 137075, year: 2011, vol: 9, page: 193, stat: Journal Article,

Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia
D'Altri, Teresa; Gonzalez, Jessica; Aifantis, Iannis; Espinosa, Lluis; Bigas, Anna
2011 Apr 1;10(7):1031-1036, Cell cycle
— id: 134230, year: 2011, vol: 10, page: 1031, stat: Journal Article,

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
Germar, Kristine; Dose, Marei; Konstantinou, Tassos; Zhang, Jiangwen; Wang, Hongfang; Lobry, Camille; Arnett, Kelly L; Blacklow, Stephen C; Aifantis, Iannis; Aster, Jon C; Gounari, Fotini
2011 Dec;108(50):20060-20065, Proceedings of the National Academy of Sciences of the United States of America
— id: 163324, year: 2011, vol: 108, page: 20060, stat: Journal Article,

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
Klinakis, Apostolos; Lobry, Camille; Abdel-Wahab, Omar; Oh, Philmo; Haeno, Hiroshi; Buonamici, Silvia; van De Walle, Inge; Cathelin, Severine; Trimarchi, Thomas; Araldi, Elisa; Liu, Cynthia; Ibrahim, Sherif; Beran, Miroslav; Zavadil, Jiri; Efstratiadis, Argiris; Taghon, Tom; Michor, Franziska; Levine, Ross L; Aifantis, Iannis
2011 May 12;473(7346):230-233, Nature
— id: 134267, year: 2011, vol: 473, page: 230, stat: Journal Article,

Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think
Lobry, Camille; Oh, Philmo; Aifantis, Iannis
2011 Sep 26;208(10):1931-1935, Journal of experimental medicine
— id: 137892, year: 2011, vol: 208, page: 1931, stat: Journal Article,

The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis
Mar, B G; Amakye, D; Aifantis, I; Buonamici, S
2011 Nov;25(11):1665-1673, Leukemia
— id: 163326, year: 2011, vol: 25, page: 1665, stat: Journal Article,

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Moran-Crusio, Kelly; Reavie, Linsey; Shih, Alan; Abdel-Wahab, Omar; Ndiaye-Lobry, Delphine; Lobry, Camille; Figueroa, Maria E; Vasanthakumar, Aparna; Patel, Jay; Zhao, Xinyang; Perna, Fabiana; Pandey, Suveg; Madzo, Jozef; Song, Chunxiao; Dai, Qing; He, Chuan; Ibrahim, Sherif; Beran, Miloslav; Zavadil, Jiri; Nimer, Stephen D; Melnick, Ari; Godley, Lucy A; Aifantis, Iannis; Levine, Ross L
2011 Jul 12;20(1):11-24, Cancer cell
— id: 135262, year: 2011, vol: 20, page: 11, stat: Journal Article,

Evaluating clonal dominance in a murine knock-in model of Jak2V617F MPN
Mullally, A; Poveromo, L; Brumme, K; Al-Shahrour, F; Lane, S W; Shih, A H; Aifantis, I; Levine, R L; Ebert, B L
2011 18 Nov 2011;118(21):-, Blood
— id: 169666, year: 2011, vol: 118, page: , stat: Journal Article,

Assessing quality and completeness of human transcriptional regulatory pathways on a genome-wide scale
Shmelkov, Evgeny; Tang, Zuojian; Aifantis, Iannis; Statnikov, Alexander
2011 ;6:15-15, Biology direct
— id: 127234, year: 2011, vol: 6, page: 15, stat: Journal Article,

PHF6 mutations in adult acute myeloid leukemia
Van Vlierberghe, P; Patel, J; Abdel-Wahab, O; Lobry, C; Hedvat, C V; Balbin, M; Nicolas, C; Payer, A R; Fernandez, H F; Tallman, M S; Paietta, E; Melnick, A; Vandenberghe, P; Speleman, F; Aifantis, I; Cools, J; Levine, R; Ferrando, A
2011 Jan;25(1):130-134, Leukemia
— id: 133886, year: 2011, vol: 25, page: 130, stat: Journal Article,

Energy addiction and lymphocyte differentiation: a new role for the liver kinase B1 kinase
Aifantis, Iannis; Sawai, Catherine
2010 Jan;40(1):19-21, European journal of immunology
— id: 106096, year: 2010, vol: 40, page: 19, stat: Journal Article,

The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation
Crusio, K M; King, B; Reavie, L B; Aifantis, I
2010 Sep 2;29(35):4865-4873, Oncogene
— id: 112034, year: 2010, vol: 29, page: 4865, stat: Journal Article,

The Notch/Hes1 pathway sustains NF-kappaB activation through CYLD repression in T cell leukemia
Espinosa, Lluis; Cathelin, Severine; D'Altri, Teresa; Trimarchi, Thomas; Statnikov, Alexander; Guiu, Jordi; Rodilla, Veronica; Ingles-Esteve, Julia; Nomdedeu, Josep; Bellosillo, Beatriz; Besses, Carles; Abdel-Wahab, Omar; Kucine, Nicole; Sun, Shao-Cong; Song, Guangchan; Mullighan, Charles C; Levine, Ross L; Rajewsky, Klaus; Aifantis, Iannis; Bigas, Anna
2010 Sep 14;18(3):268-281, Cancer cell
— id: 133795, year: 2010, vol: 18, page: 268, stat: Journal Article,

RNA-binding proteins come out of the shadows
Nedjic, Jelena; Aifantis, Iannis
2010 Aug;11(8):697-698, Nature immunology
— id: 111392, year: 2010, vol: 11, page: 697, stat: Journal Article,

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex
Reavie, Linsey; Della Gatta, Giusy; Crusio, Kelly; Aranda-Orgilles, Beatriz; Buckley, Shannon M; Thompson, Benjamin; Lee, Eugine; Gao, Jie; Bredemeyer, Andrea L; Helmink, Beth A; Zavadil, Jiri; Sleckman, Barry P; Palomero, Teresa; Ferrando, Adolfo; Aifantis, Iannis
2010 Mar;11(3):207-215, Nature immunology
— id: 159179, year: 2010, vol: 11, page: 207, stat: Journal Article,

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
Buonamici, Silvia; Trimarchi, Thomas; Ruocco, Maria Grazia; Reavie, Linsey; Cathelin, Severine; Mar, Brenton G; Klinakis, Apostolos; Lukyanov, Yevgeniy; Tseng, Jen-Chieh; Sen, Filiz; Gehrie, Eric; Li, Mengling; Newcomb, Elizabeth; Zavadil, Jiri; Meruelo, Daniel; Lipp, Martin; Ibrahim, Sherif; Efstratiadis, Argiris; Zagzag, David; Bromberg, Jonathan S; Dustin, Michael L; Aifantis, Iannis
2009 Jun 18;459(7249):1000-1004, Nature
— id: 105354, year: 2009, vol: 459, page: 1000, stat: Journal Article,

Hedgehog and hematopoietic stem cell differentiation Don't believe the hype!
Gao, J; Aifantis, I
2009 DEC 1 ;8(23):3789-3790, Cell cycle
— id: 105637, year: 2009, vol: 8, page: 3789, stat: Journal Article,

Hedgehog and hematopoietic stem cell differentiation: don't believe the hype!
Gao, Jie; Aifantis, Iannis
2009 Dec;8(23):3789-3790, Cell cycle
— id: 163327, year: 2009, vol: 8, page: 3789, stat: Journal Article,

Hedgehog signaling is dispensable for adult hematopoietic stem cell function
Gao, Jie; Graves, Stephanie; Koch, Ute; Liu, Suqing; Jankovic, Vladimir; Buonamici, Silvia; El Andaloussi, Abdeljabar; Nimer, Stephen D; Kee, Barbara L; Taichman, Russell; Radtke, Freddy; Aifantis, Iannis
2009 Jun 5;4(6):548-558, Cell stem cell
— id: 99328, year: 2009, vol: 4, page: 548, stat: Journal Article,

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Real, Pedro J; Tosello, Valeria; Palomero, Teresa; Castillo, Mireia; Hernando, Eva; de Stanchina, Elisa; Sulis, Maria Luisa; Barnes, Kelly; Sawai, Catherine; Homminga, Irene; Meijerink, Jules; Aifantis, Iannis; Basso, Giuseppe; Cordon-Cardo, Carlos; Ai, Walden; Ferrando, Adolfo
2009 Jan;15(1):50-58, Nature medicine
— id: 105355, year: 2009, vol: 15, page: 50, stat: Journal Article,

Molecular pathogenesis of T-cell leukaemia and lymphoma
Aifantis, Iannis; Raetz, Elizabeth; Buonamici, Silvia
2008 May;8(5):380-390, Nature reviews. Immunology
— id: 79384, year: 2008, vol: 8, page: 380, stat: Journal Article,

Knockdown of CCR7 or Its Ligands Causes a Loss of Central Nervous System Involvement in Notch1 Induced T-ALL
Buonamici, S; Trimarchi, T; Klinakis, A; Reavie, L; Mar, BG; Gehrie, E; Kuan, EL; Randolph, GJ; Bromberg, J; Aifantis, I
2008 NOV 16 ;112(11):81-81, Blood
— id: 93280, year: 2008, vol: 112, page: 81, stat: Journal Article,

Hexamethylene bisacetamide as a treatment for T-cell leukemia (T-ALL)
Buonamici, Silvia; Aifantis, Iannis
2008 May;32(5):689-690, Leukemia research
— id: 81332, year: 2008, vol: 32, page: 689, stat: Journal Article,

Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
Johnson, Kristen; Hashimshony, Tamar; Sawai, Catherine M; Pongubala, Jagan M R; Skok, Jane A; Aifantis, Iannis; Singh, Harinder
2008 Mar;28(3):335-345, Immunity
— id: 81074, year: 2008, vol: 28, page: 335, stat: Journal Article,

Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid
Mandal, Malay; Crusio, Kelly M; Meng, Fanyong; Liu, Suqing; Kinsella, Marcus; Clark, Marcus R; Takeuchi, Osamu; Aifantis, Iannis
2008 Dec 30;105(52):20840-20845, Proceedings of the National Academy of Sciences of the United States of America
— id: 105356, year: 2008, vol: 105, page: 20840, stat: Journal Article,

Inhibition of NOTCH1 Signaling and Glucocorticoid Therapy in T-ALL
Real, PJ; Tosello, V; Palomero, T; Castillo, M; Sawai, C; Sulis, ML; Meijerink, JPP; Basso, G; Aifantis, I; Cordon-Cardo, C; Ferrando, AA
2008 NOV 16 ;112(11):116-116, Blood
— id: 93281, year: 2008, vol: 112, page: 116, stat: Journal Article,

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
Thompson, Benjamin J; Jankovic, Vladimir; Gao, Jie; Buonamici, Silvia; Vest, Alan; Lee, Jennifer May; Zavadil, Jiri; Nimer, Stephen D; Aifantis, Iannis
2008 Jun 9;205(6):1395-1408, Journal of experimental medicine
— id: 79221, year: 2008, vol: 205, page: 1395, stat: Journal Article,

The Effect of Ubiquitination on Hematopoietic Stem Cell Differentiation and Transformation
Aifantis, Iannis
[S.l.] : NIH, 2007,
— id: 1431, year: 2007, vol: , page: , stat: ,

Notches, NFkappaBs and the making of T cell leukemia
Aifantis, Iannis; Vilimas, Tomas; Buonamici, Silvia
2007 Feb;6(4):403-406, Cell cycle
— id: 71422, year: 2007, vol: 6, page: 403, stat: Journal Article,

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Thompson, Benjamin J; Buonamici, Silvia; Sulis, Maria Luisa; Palomero, Teresa; Vilimas, Tomas; Basso, Giuseppe; Ferrando, Adolfo; Aifantis, Iannis
2007 Aug 6;204(8):1825-1835, Journal of experimental medicine
— id: 73913, year: 2007, vol: 204, page: 1825, stat: Journal Article,

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
Vilimas, Tomas; Mascarenhas, Joaquina; Palomero, Teresa; Mandal, Malay; Buonamici, Silvia; Meng, Fanyong; Thompson, Benjamin; Spaulding, Christina; Macaroun, Sami; Alegre, Maria-Luisa; Kee, Barbara L; Ferrando, Adolfo; Miele, Lucio; Aifantis, Iannis
2007 Jan;13(1):70-77, Nature medicine
— id: 69487, year: 2007, vol: 13, page: 70, stat: Journal Article,

The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells
Aifantis, Iannis; Bassing, Craig H; Garbe, Annette I; Sawai, Katie; Alt, Frederick W; von Boehmer, Harald
2006 Jun 12;203(6):1543-1550, Journal of experimental medicine
— id: 68860, year: 2006, vol: 203, page: 1543, stat: Journal Article,

Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor
Aifantis, Iannis; Mandal, Malay; Sawai, Katie; Ferrando, Adolfo; Vilimas, Tomas
2006 Feb;209:159-169, Immunological reviews
— id: 68866, year: 2006, vol: 209, page: 159, stat: Journal Article,

A unique function for cyclin D3 in early B cell development
Cooper, A Byron; Sawai, Catherine M; Sicinska, Ewa; Powers, Sarah E; Sicinski, Piotr; Clark, Marcus R; Aifantis, Iannis
2006 May;7(5):489-497, Nature immunology
— id: 68862, year: 2006, vol: 7, page: 489, stat: Journal Article,

Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus
El Andaloussi, Abdeljabar; Graves, Stephanie; Meng, Fanyong; Mandal, Malay; Mashayekhi, Mona; Aifantis, Iannis
2006 Apr;7(4):418-426, Nature immunology
— id: 68863, year: 2006, vol: 7, page: 418, stat: Journal Article,

Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms
Reschly, Erica J; Spaulding, Christina; Vilimas, Tomas; Graham, W Vallen; Brumbaugh, Rachel L; Aifantis, Iannis; Pear, Warren S; Kee, Barbara L
2006 May 15;107(10):4115-4121, Blood
— id: 68865, year: 2006, vol: 107, page: 4115, stat: Journal Article,

A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus
Scimone, M Lucila; Aifantis, Iannis; Apostolou, Irina; von Boehmer, Harald; von Andrian, Ulrich H
2006 May 2;103(18):7006-7011, Proceedings of the National Academy of Sciences of the United States of America
— id: 68861, year: 2006, vol: 103, page: 7006, stat: Journal Article,

The pre-B cell receptor in B cell development: recent advances, persistent questions and conserved mechanisms
Clark, M R; Cooper, A B; Wang, L D; Aifantis, I
2005 ;290:87-103, Current topics in microbiology & immunology
— id: 68864, year: 2005, vol: 290, page: 87, stat: Journal Article,

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
Mandal, Malay; Borowski, Christine; Palomero, Teresa; Ferrando, Adolfo A; Oberdoerffer, Philipp; Meng, Fanyong; Ruiz-Vela, Antonio; Ciofani, Maria; Zuniga-Pflucker, Juan-Carlos; Screpanti, Isabella; Look, A Thomas; Korsmeyer, Stanley J; Rajewsky, Klaus; von Boehmer, Harald; Aifantis, Iannis
2005 Feb 21;201(4):603-614, Journal of experimental medicine
— id: 68868, year: 2005, vol: 201, page: 603, stat: Journal Article,

Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages
Oberdoerffer, Philipp; Kanellopoulou, Chryssa; Heissmeyer, Vigo; Paeper, Corinna; Borowski, Christine; Aifantis, Iannis; Rao, Anjana; Rajewsky, Klaus
2005 May;25(10):3896-3905, Molecular & cellular biology
— id: 68867, year: 2005, vol: 25, page: 3896, stat: Journal Article,

Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development
Borowski, Christine; Li, Xiaoyan; Aifantis, Iannis; Gounari, Fotini; von Boehmer, Harald
2004 Mar 1;199(5):607-615, Journal of experimental medicine
— id: 68869, year: 2004, vol: 199, page: 607, stat: Journal Article,

Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential
Martin, Colin H; Aifantis, Iannis; Scimone, M Lucila; von Andrian, Ulrich H; Reizis, Boris; von Boehmer, Harald; Gounari, Fotini
2003 Sep;4(9):866-873, Nature immunology
— id: 68871, year: 2003, vol: 4, page: 866, stat: Journal Article,

Requirement for cyclin D3 in lymphocyte development and T cell leukemias
Sicinska, Ewa; Aifantis, Iannis; Le Cam, Laurent; Swat, Wojciech; Borowski, Christine; Yu, Qunyan; Ferrando, Adolfo A; Levin, Steven D; Geng, Yan; von Boehmer, Harald; Sicinski, Piotr
2003 Dec;4(6):451-461, Cancer cell
— id: 68870, year: 2003, vol: 4, page: 451, stat: Journal Article,

Thymic selection revisited: how essential is it?
von Boehmer, Harald; Aifantis, Iannis; Gounari, Fotini; Azogui, Orly; Haughn, Loralee; Apostolou, Irina; Jaeckel, Elmar; Grassi, Fabio; Klein, Ludger
2003 Feb;191:62-78, Immunological reviews
— id: 68872, year: 2003, vol: 191, page: 62, stat: Journal Article,

A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development
Aifantis, Iannis; Borowski, Christine; Gounari, Fotini; Lacorazza, H Daniel; Nikolich-Zugich, Janko; von Boehmer, Harald
2002 May;3(5):483-488, Nature immunology
— id: 68874, year: 2002, vol: 3, page: 483, stat: Journal Article,

On the brink of becoming a T cell
Borowski, Christine; Martin, Colin; Gounari, Fotini; Haughn, Loralee; Aifantis, Iannis; Grassi, Fabio; von Boehmer, Harald
2002 Apr;14(2):200-206, Current opinion in immunology
— id: 68876, year: 2002, vol: 14, page: 200, stat: Journal Article,

Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene
Gounari, Fotini; Aifantis, Iannis; Martin, Colin; Fehling, Hans-Joerg; Hoeflinger, Sonja; Leder, Philip; von Boehmer, Harald; Reizis, Boris
2002 May;3(5):489-496, Nature immunology
— id: 68875, year: 2002, vol: 3, page: 489, stat: Journal Article,

Positive selection by the pre-TCR yields mature CD8+ T cells
Ito, Yuriko; Arai, Satoko; van Oers, Nicolai S C; Aifantis, Iannis; von Boehmer, Harald; Miyazaki, Toru
2002 Nov 1;169(9):4913-4919, Journal of immunology (1950)
— id: 68873, year: 2002, vol: 169, page: 4913, stat: Journal Article,

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT
Aifantis, I; Gounari, F; Scorrano, L; Borowski, C; von Boehmer, H
2001 May;2(5):403-409, Nature immunology
— id: 68878, year: 2001, vol: 2, page: 403, stat: Journal Article,

Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development
Gounari, F; Aifantis, I; Khazaie, K; Hoeflinger, S; Harada, N; Taketo, M M; von Boehmer, H
2001 Sep;2(9):863-869, Nature immunology
— id: 68877, year: 2001, vol: 2, page: 863, stat: Journal Article,

Nitric oxide production by pre-implantation embryos in response to embryotoxic factors
Athanassakis, I; Aifantis, I; Baritakis, S; Farmakiotis, V; Koumantakis, E; Vassiliadis, S
2000 ;10(3):169-176, Cellular physiology & biochemistry
— id: 68880, year: 2000, vol: 10, page: 169, stat: Journal Article,

Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex
Aifantis, I; Feinberg, J; Fehling, H J; Di Santo, J P; von Boehmer, H
1999 Jul 5;190(1):141-144, Journal of experimental medicine
— id: 68884, year: 1999, vol: 190, page: 141, stat: Journal Article,

Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein
Aifantis, I; Pivniouk, V I; Gartner, F; Feinberg, J; Swat, W; Alt, F W; von Boehmer, H; Geha, R S
1999 Oct 18;190(8):1093-1102, Journal of experimental medicine
— id: 68882, year: 1999, vol: 190, page: 1093, stat: Journal Article,

Inhibition of nitric oxide production rescues LPS-induced fetal abortion in mice
Athanassakis, I; Aifantis, I; Ranella, A; Giouremou, K; Vassiliadis, S
1999 Jun;3(3):216-224, Nitric oxide : biology & chemistry
— id: 68883, year: 1999, vol: 3, page: 216, stat: Journal Article,

Expression of corticotrophin-releasing hormone in the mouse uterus: participation in embryo implantation
Athanassakis, I; Farmakiotis, V; Aifantis, I; Gravanis, A; Vassiliadis, S
1999 Nov;163(2):221-227, Journal of endocrinology
— id: 68881, year: 1999, vol: 163, page: 221, stat: Journal Article,

The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development
Di Santo, J P; Aifantis, I; Rosmaraki, E; Garcia, C; Feinberg, J; Fehling, H J; Fischer, A; von Boehmer, H; Rocha, B
1999 Feb 1;189(3):563-574, Journal of experimental medicine
— id: 68886, year: 1999, vol: 189, page: 563, stat: Journal Article,

The impact of pre-T-cell receptor signals on gene expression in developing T cells
von Boehmer, H; Aifantis, I; Azogui, O; Saint-Ruf, C; Grassi, F
1999 ;64:283-289, Cold Spring Harbor symposia on quantitative biology
— id: 68879, year: 1999, vol: 64, page: 283, stat: Journal Article,

Pleiotropic changes controlled by the pre-T-cell receptor
von Boehmer, H; Aifantis, I; Feinberg, J; Lechner, O; Saint-Ruf, C; Walter, U; Buer, J; Azogui, O
1999 Apr;11(2):135-142, Current opinion in immunology
— id: 68885, year: 1999, vol: 11, page: 135, stat: Journal Article,

On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment
Aifantis, I; Azogui, O; Feinberg, J; Saint-Ruf, C; Buer, J; von Boehmer, H
1998 Nov;9(5):649-655, Immunity
— id: 68888, year: 1998, vol: 9, page: 649, stat: Journal Article,

Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment
von Boehmer, H; Aifantis, I; Azogui, O; Feinberg, J; Saint-Ruf, C; Zober, C; Garcia, C; Buer, J
1998 Oct;165:111-119, Immunological reviews
— id: 68887, year: 1998, vol: 165, page: 111, stat: Journal Article,

Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus
Aifantis, I; Buer, J; von Boehmer, H; Azogui, O
1997 Nov;7(5):601-607, Immunity
— id: 68889, year: 1997, vol: 7, page: 601, stat: Journal Article,

Role of different T cell receptors in the development of pre-T cells
Buer, J; Aifantis, I; DiSanto, J P; Fehling, H J; von Boehmer, H
1997 May 5;185(9):1541-1547, Journal of experimental medicine
— id: 68891, year: 1997, vol: 185, page: 1541, stat: Journal Article,

T-cell development in the absence of the pre-T-cell receptor
Buer, J; Aifantis, I; DiSanto, J P; Fehling, H J; von Boehmer, H
1997 Jun 1;57(1-3):5-8, Immunology letters
— id: 68890, year: 1997, vol: 57, page: 5, stat: Journal Article,