Ioannis Aifantis

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Ioannis Aifantis

Professor, Department of Pathology
Pathology

Contact Info

212/263-9898
Ioannis.Aifantis@nyumc.org

Education

1994-1996 — Masters in Science, "Molecular Biology and Genetics", University of Crete, Greece, Graduate Education
1996-1999 — Ph.D., "Immunology", University of Paris V, France, Graduate Education
1999-2003 — Harvard Medical School (Dana Farber Cancer Institute), USA, PostDoctoral Training

Research Interests

Our laboratory studies the molecular mechanisms controlling hematopoietic stem cell (HSC) self-renewal, differentiation and transformation. More specifically we focus on the regulation of HSC cell cycle entry and on the effects of Notch signaling in stem cell differentiation. Finally, we study the role of the Notch pathway as an oncogenic trigger in acute lymphoblastic leukemia. Our goal is to design novel therapies that will target and suppress Notch transforming activity in vivo.

Research Documents


TET1 is a tumor suppressor of hematopoietic malignancy
Cimmino, Luisa; Dawlaty, Meelad M; Ndiaye-Lobry, Delphine; Yap, Yoon Sing; Bakogianni, Sofia; Yu, Yiting; Bhattacharyya, Sanchari; Shaknovich, Rita; Geng, Huimin; Lobry, Camille; Mullenders, Jasper; King, Bryan; Trimarchi, Thomas; Aranda-Orgilles, Beatriz; Liu, Cynthia; Shen, Steven; Verma, Amit K; Jaenisch, Rudolf; Aifantis, Iannis
2015-04-20; 1529-2916,Nature immunology - id: 1532762, year: 2015 JOURNAL ARTICLE

The methylcytosine dioxygenase tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells
Ichiyama, Kenji; Chen, Tingting; Wang, Xiaohu; Yan, Xiaowei; Kim, Byung-Seok; Tanaka, Shinya; Ndiaye-Lobry, Delphine; Deng, Yuhua; Zou, Yanli; Zheng, Pan; Tian, Qiang; Aifantis, Iannis; Wei, Lai; Dong, Chen
2015-04-27; 1097-4180,Immunity - id: 1544192, year: 2015 Journal Article

FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification
Kourtis, Nikos; Moubarak, Rana S; Aranda-Orgilles, Beatriz; Lui, Kevin; Aydin, Iraz T; Trimarchi, Thomas; Darvishian, Farbod; Salvaggio, Christine; Zhong, Judy; Bhatt, Kamala; Chen, Emily I; Celebi, Julide T; Lazaris, Charalampos; Tsirigos, Aristotelis; Osman, Iman; Hernando, Eva; Aifantis, Iannis
2015-03-01; 1465-7392,Nature cell biology - id: 1474022, year: 2015 JOURNAL ARTICLE

Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia
Shih, Alan H; Jiang, Yanwen; Meydan, Cem; Shank, Kaitlyn; Pandey, Suveg; Barreyro, Laura; Antony-Debre, Ileana; Viale, Agnes; Socci, Nicholas; Sun, Yongming; Robertson, Alexander; Cavatore, Magali; de Stanchina, Elisa; Hricik, Todd; Rapaport, Franck; Woods, Brittany; Wei, Chen; Hatlen, Megan; Baljevic, Muhamed; Nimer, Stephen D; Tallman, Martin; Paietta, Elisabeth; Cimmino, Luisa; Aifantis, Iannis; Steidl, Ulrich; Mason, Chris; Melnick, Ari; Levine, Ross L
2015-04-20; 1878-3686,Cancer cell - id: 1532192, year: 2015 Journal Article

The Pre-BCR to the Rescue: Therapeutic Targeting of Pre-B Cell ALL
Trimarchi, Thomas; Aifantis, Iannis
2015-03-16; 1535-6108,Cancer cell - id: 1494912, year: 2015 Journal Article