Biochemistry Department Publications - 1999

Borowiec, J.A., Gillette, T.G., Smelkova, N.V. and Iftode, C. (1999). Analysis of DNA replication complexes by DNA probing. In: Eukaryotic DNA replication: a practical approach. S. Cotterill, ed. Oxford University Press, Oxford. pp. 245-272..

Chang, M., French-Cornay, D., Fan, H.Y., Klein, H., Denis, C.L., and Jaehning, J. A.(1999). A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p and Ccr4p plays a role in protein kinase C signaling. Mol. Cell. Biol. 19: 1056-1067.

Gusarov I. and Nudler E. (1999). The mechanism of intrinsic transcription termination. Mol. Cell. 3: 495-504.

Hach, A., Hon., T., and Zhang, L. (1999). A new class of repression modules is critical for heme regulation of the yeast transcripional activator HAP1. Mol.Cell. Biol. 19: 4324-4333.

Hegde, R.S., Androphy E. (1998). Crystal structure of the E2 DNA-binding domain from Human papillomavirus Type 16: Implications for its DNA binding-site selection mechanism. J. Mol. Biol. In press.

Hon, T., Hach, A., Tamalis, D., Zhu, Y. and Zhang, L. (1999). The yeast heme responsive transcriptional activator Hap1 is a preexisting dimer in the absence of heme. J. Biol. Chem. 274: 22770-22774.

Iftode, C., Daniely, Y., and Borowiec, J.A. (1999). Replication protein A: The eukaryotic SSB. Crit. Rev. Biochem. Mol. Biol. In press.

Kandel, E. and Nudler, E. (1999) Template switching by RNA polymerase II in vivo: evidence and implications from a retroviral system. Manuscript submitted to Science.

King, DA., Zhang, L., Guarente, L., and Marmorstein, R (1999). Structure of a HAP1/DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein. Nature Structure Biology. 6: 64-71.

King, DA., Zhang, L., Guarente, L., and Marmorstein, R (1999). Structure of a HAP1-18/DNA complex implicates direct allosteric effect of protein-DNA interactions on transcriptional activation. Nature Structure Biology. 6: 22-27.

Klein, N. Bouchard, M. and Schneider, R.J. (1999). An Essential role for Src activation in HBV replication. Submitted.

Krikun, G., Schatz, F., Mackman, N., Guller, S., Lockwood, C.J. (1998). Transcriptional regulation of the tissue factor gene by progestins in human endometrial stromal cells. J. Clin. Endocrinol. Metab. (In Press).

Laroia, G., Cuesta, R., Brewer, G. and Schneider, R. (1999). Control of mRNA Decay by Heat Shock Ubiquitin-Proteasome Pathway. Science 284: 499-502

Lee-Huang, S., Huang, P., Sun, Y., Huang, P., Kung, H.F., Blithe, D., and Chen, H-C. (1999) Lysozyme and RNases as anti-HIV components in B-core preparations of human chorionic gonadotropin. Proc. Natl. Acad. Sci. 96: 2678-2681.

Lee-Huang, S., Huang, P., Sun, Y., Chen, H-C,, Kung, H.F., Huang, PL, and Murphy, WJ. (1999). Inhibition of human breast tumor MDA-MB-231 xenografts and HER2 Expression in SCID mice by anti-tumor agents GAP31 and MAP30. J. NCI. (In press).

Ogden, A.T., Nunes, I., Ko, K., Wu, S., Hines, C.S., Wang, A., Hegde, R.S., and Lang, R.A. (1998). GRIFIN, a novel lens-specific protein related to the galectin family. J. of Biol. Chem. In press.

Murphy, G., Solski, P., Jillian, S., Perez de la Ossa, P., D'Eustachio, P., Der, C., and Rush, M. (1999). Cellular Functions of TC10, a Rho Family GTPase: Regulation of Morphology, Signal Transduction, and Cell Growth. Oncogene. In Press.

Nielsen, K.L., McLennan, N., Masters, M., Cowan, N.J. and Lewis, S.A. (1999) A single ring mitrocondrial chaperonin (Hsp60/Hsp10) can substitute for GroEL/GroES in vivo. J. Bacteriology. In Press.

Nudler, Evgeny (1999) Transcription Elongation: Structural Basis and Mechanisms. J.Mol. Biol. 288: 1-12.

Rozenberg, H., Rabinovich, D., Frolow, F., Hegde, R.S., Shakked, Z. (1998). Structural code for DNA recognition in gene regulation revealed by crystal structures of papillomavirus E2-DNA targets. Proceedings of the National Academy of Science. In Press.

Schneiter, R., Guerra, C.E., Lampl, M., Kohlwein, S.D., and Klein, H.L. (1999) Characterization of a novel cold-sensitive allele of acetyl=coA carboxylase (acc1cs) that displays intragenic complementation and is lethal with the hpr1 mutant of Saccharomyces cerevisiae. Submitted.

Schneiter, R., Guerra, C.E., Lampl, M., Zellnig, G., ,Klein, H.L. and Kohlwein, S.D.(1999). A novel cold-sensitive allele of the rate-limiting enzyme of fatty acid synthesis, acetyl-CoA carboxylase ACC1, affects mitochondiral structure and displays intragenic complementation with mtr7, a temperature-sensitive allele of ACC1. Submitted.

Schreiber, C.A., Wan, L., Sun, Y.T., Lu, L., Krey, L.C. and Lee-Huang, S. (1999). Anti-HIV agents, MAP30 and GAP31 are not toxic to human spermatocytes: Potential use of these agents against sexual transmission of HIV-1. Steril Fertil. In Press.

Tian, G., Bhamidipati, A., Lewis, S.A. and Cowan, N.J. (1999). Tubulin folding cofactors as GTPase activity proteins: GTP hydrolysis and the assembly of the A/B tubulin heterondimers. J.Biol. Chem in press.

Wang, XY., Marquardt, J., Wingfield, P., Lee-Huang, S., Torchia, D. and Bax, A.(1999) Simultaneous measurement of 1H-15N,1h-13C' and 15N-13C' dipole coupling in a perdeuterated 30 kDa protein dissolved in a dilute liquid crystalline phase. JACS. In press.

Zhang, L., and Hach, A. (1999) Molecular mechanism of heme signaling in yeast: The transcriptional activator Hap1 serves as the key mediator. Cell. Mol Life Sci.. In press.

Zhu, Y., Hon, T., and Zhang, L. (1999) Heme initiates changes in the expression of a wide array of genes during the early erythroid differentiation stage. Biochem. Biophys. Res. Comm. 258: 87-93.

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